 Kenya Honda
Name: Kenya Honda
Sex: male
Date of birth: 4 Jan. 1969
Nationality: Japanese
Title & Address:
Associate Professor
Department of Immunology
Graduate School of Medicine, The University of Tokyo
Hongo 7-3-1, Bunkyo-ku,
Tokyo 113-0033, Japan
Tel: +81-3-5841-3373 Fax: +81-3-5841-3450
Email: kenya@m.u-tokyo.ac.jp
Visiting Researcher
Laboratory for Immune Cell System
RIKEN Research Center for Allergy and Immunology (RCAI)
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama, 230-0045 JAPAN
TEL: +81-45-503-7024 FAX: +81-45-503-9271
e-mail: kenya@rcai.riken.jp
Education:
1994 M.D.
Kobe University, School of Medicine, Japan
Japanese Medical License Registration (No. 365677)
2001 Ph.D. (Medical Science)
Kyoto University, Graduate School of Medicine, Japan
Research Interests: Lymphoid organogenesis
Professional Experience:
2001-2007 Assistant Professor
Dept. of Immunology
Graduate School of Medicine and Faculty of Medicine
University of Tokyo, Japan
Research Interests: Signal transduction in innate immune system
2007-2009 Associate Professor
Laboratory of Immune Regulation
Department of Microbiology and Immunology
Graduate School of Medicine, Osaka University
Research Interests: Intestinal immune system
2008-2010 PRESTO Researcher
Japan Science and Technology Agency
2009- present Associate Professor
Department of Immunology
Graduate School of Medicine, The University of Tokyo
Research Interests: Microbiome and Intestinal immune system
2012- present Visiting Researcher
Laboratory for Immune Cell System (Dr. Shigeo Koyasu lab)
RIKEN Research Center for Allergy and Immunology (RCAI)
2012- present CREST Researcher
Japan Science and Technology Agency
Honors and Awards:
2006 Incitement Award of the Japanese Society for Immunology.
2011-2012 Funding Program for Next Generation World-Leading Researchers, Japan Society for the Promotion of Science
Selected Publications:
2013
・ Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I, Cheroutre H. Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol. 2013 Jan 20
2012
・ Honda K*, Littman DR*. The microbiome in infectious disease and inflammation. Ann Rev Immunol. 30:759-95. (2012) *corresponding author
・ Ivanov II*, Honda K*. Intestinal commensal microbes as immune modulators. Cell Host Microbe. 12:496-508. (2012) *corresponding author
・ Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol. 13:659-66. (2012)
2011
・ Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K and Honda K*. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331:337-341 (2011) *corresponding author
・ Atarashi K, Honda K*. Microbiota in autoimmunity and tolerance. Curr Opin Immunol. 23:761-8 (2011)
2010
・ Savitsky DA, Yanai H, Tamura T, Taniguchi T, Honda K. Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci U S A. 107:10154-9. (2010)
・ Tanoue T, Umesaki Y, Honda K. Immune responses to gut microbiota-commensals and pathogens. Gut Microbes. 1:224-233. (2010)
2009
・ Honda K, Takeda K. Regulatory mechanisms of immune responses to intestinal bacteria. Mucosal Immunol. 2:187-96. (2009)
・ Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K*, Littman DR*. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485-98. (2009) *corresponding author
・ Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani L, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 462:99-103. (2009)
2008
・ Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A. 105:20446-51. (2008)
・ Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K*, Takeda K*. ATP drives lamina propria T(H)17 cell differentiation. Nature 455:808-12. (2008) *corresponding author
・ Kano SI., Sato K., Morishita Y., Vollstedt S., Kim S., Bishop K., Honda K., Kubo M., Taniguchi T. The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and T(H)1 versus T(H)-17 differentiation of CD4(+) T cells. Nature Immunology 9: 34–41. (2008).
2007
・ Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448:501-5. (2007)
・ Yanai, H., H.M. Chen, T. Inuzuka, S. Kondo, T.W. Mak, A. Takaoka, K. Honda, and T. Taniguchi. Role of IRF5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci U S A. 104:3402-3407. (2007)
2006
・ Negishi, H., Y. Fujita, H. Yanai, S. Sakaguchi, X. Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba, T. Taniguchi, and K. Honda. Evidence for licensing of IFN--induced IRF1 transcription factor by MyD88 in TLR-dependent gene induction program. Proc Natl Acad Sci U S A. 103:15136-15141. (2006).
・ Honda, K., A. Takaoka, and T. Taniguchi. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 25:349-360. (2006).
・ Honda, K., and T. Taniguchi. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nature Reviews Immunology 6:644-658. (2006).
2005
・ Negishi, H., Y. Ohba, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi, and K. Honda. Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A. 102:15989-15994. (2005).
・ Takaoka, A., H. Yanai, S. Kondo, G. Duncan, H. Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. W. Mak, and T. Taniguchi. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434:243-249. (2005).
・ Honda, K., H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434:772-777. (2005).
・ Honda, K., Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434:1035-1040. (2005).
2004
・ Honda, K., H. Yanai, T. Mizutani, H. Negishi, N. Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W. C. Yeh, and T. Taniguchi. Role of a transductional- transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A. 101:15416-15421. (2004).
・ Honda, K., T. Mizutani, and T. Taniguchi. Negative regulation of IFN-/ signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. Proc Natl Acad Sci U S A. 101:2416-2421. (2004).
2003
・ Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. Honda, and T. Taniguchi. Integration of interferon-/ signalling to p53 responses in tumour suppression and antiviral defence. Nature 424:516-523. (2003).
・ Honda, K., S. Sakaguchi, C. Nakajima, A. Watanabe, H. Yanai, M. Matsumoto, T. Ohteki, T. Kaisho, A. Takaoka, S. Akira, T. Seya, and T. Taniguchi. Selective contribution of IFN-/ signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A. 100:10872-10877. (2003).
~2001
・ Honda, K*., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., and Nishikawa, S.I. Molecular basis for hematopoietic / mesenchymal interaction during initiation of Peyer’s patch organogenesis. J. Exp. Med. 193:621-630 (2001). *corresponding author
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