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Professional Experience and Education :
2008-Present: Associate Professor, Cancer Genomics Project, University
of Tokyo
2006 - 2008: Associate Professor, The 21st century COE program,
Graduate School of Medicine,University of Tokyo
2002 - 2006: Associate Professor, Department of Regeneration
Medicine for hematopoiesis,
Graduate School of Medicine, University of Tokyo
1996 –2002: Assistant Professor of Medicine, University of Tokyo
1995 –1996: Research fellow of Japan Society for the Promotion
of Science
1994 –1995: Clinical Associate, University of Tokyo
1989 –1994: PhD program, University of Tokyo
1988 –1989: Postgraduate clinical training in internal medicine
1983 –1988: Undergraduate/MD program, School of Medicine,University
of Tokyo Awards:
1996 Erwin von Berz Prize
1997 Incitement Award of the Japanese Cancer Association
2010 Japanese Cancer Association Mauverney Prize
2012 Nice STEP researcher 2011 Publications 1. Yamagishi M, Nakano K, Myiyake A, Yamochi T, Kagami T, Tsutsumi
A, Sato-Otsubo A, Muto S, Utsunomiya A, Yamaguchi K, Ogawa S, Watanabe
T. Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway
in adult T-cell leukemia and other cancers. Cancer Cell. in press.
2. Shiba N, Hasegawa D, Park M, Murata C, Sato A, Ogawa O, Yagasaki
H, Manabe A, Arakawa H, Ogawa S, Hayashi Y. CBL Mutation in Familial Platelet
Disorder with Propensity to Acute Myeloid Leukemia (FPD/AML) Patient in
a Japanese Pedigree with RUNX1 Mutation Blood. in press.
3. Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui
K, RuNan W, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K,
Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami
T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I. Extensive gene deletions
in Japanese patients with Diamond–Blackfan anemia. Blood. in press.
4. Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto
R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka
M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama
K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler
HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent
pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478:64-69.
Prepublished on 2011/09/13 as DOI 10.1038/nature10496.
5. Yoshida K, Sanada M, Kato M, Kawahata R, Matsubara A, Takita
J, Shih LY, Mori H, Koeffler HP, Ogawa S. A nonsense mutation of IDH1
in myelodysplastic syndromes and related disorders. Leukemia. 2011;25(1):184-186.
Prepublished on 2010/10/22 as DOI leu2010241 [pii]
10.1038/leu.2010.241.
6. Thoennissen NH, Lasho T, Thoennissen GB, Ogawa S, Tefferi
A, Koeffler HP. Novel CUX1 missense mutation in association with 7q- at
leukemic transformation of MPN. Am J Hematol. 2011;86(8):703-705. Prepublished
on 2011/06/16 as DOI 10.1002/ajh.22069.
7. Takita J, Chen Y, Okubo J, Sanada M, Adachi M, Ohki K, Nishimura
R, Hanada R, Igarashi T, Hayashi Y, Ogawa S. Aberrations of NEGR1 on 1p31
and MYEOV on 11q13 in neuroblastoma. Cancer Sci. 2011. Prepublished on
2011/06/01 as DOI 10.1111/j.1349-7006.2011.01995.x.
8. Takahashi K, Oka A, Mizuguchi M, Saitoh M, Takita J, Sato
A, Mimaki M, Kato M, Ogawa S, Igarashi T. Interstitial deletion of 13q14.13-q32.3
presenting with Arima syndrome and bilateral retinoblastoma. Brain & development.
2011;33(4):353-356. Prepublished on 2010/08/24 as DOI 10.1016/j.braindev.2010.06.014.
9. Shiba N, Park MJ, Taki T, Takita J, Hiwatari M, Kanazawa T,
Sotomatsu M, Ishii E, Arakawa H, Ogawa S, Hayashi Y. CBL mutations in
infant acute lymphoblastic leukaemia. Br J Haematol. 2011. Prepublished
on 2011/10/13 as DOI 10.1111/j.1365-2141.2011.08900.x.
10. Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo
Y, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M. Cas-L regulates
myeloid cell motility and suppresses progression of leukemia induced by
p210Bcr/Abl. Cancer science. 2011. Prepublished on 2011/08/19 as DOI 10.1111/j.1349-7006.2011.02066.x.
11. Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama
H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M,
Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required
for proper mast cell distribution and mucosal immunity in the intestine.
Blood. 2011;117(1):128-134. Prepublished on 2010/10/26 as DOI 10.1182/blood-2010-07-289611.
12. Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo
J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S. IDH1
and IDH2 mutations are rare in pediatric myeloid malignancies. Leukemia.
2011;25(2):382-384. Prepublished on 2011/01/15 as DOI leu2010307 [pii]
10.1038/leu.2010.307.
13. Ogawa S, Takita J, Sanada M, Hayashi Y. Oncogenic mutations
of ALK in neuroblastoma. Cancer Sci. 2011;102(2):302-308. Prepublished
on 2011/01/06 as DOI 10.1111/j.1349-7006.2010.01825.x.
14. Koren-Michowitz M, Sato-Otsubo A, Nagler A, Haferlach T,
Ogawa S, Koeffler HP. Older patients with normal karyotype acute myeloid
leukemia have a higher rate of genomic changes compared to young patients
as determined by SNP array analysis. Leuk Res. 2011. Prepublished on 2011/11/11
as DOI 10.1016/j.leukres.2011.10.013.
15. Katagiri T, Sato-Otsubo A, Kashiwase K, Morishima S, Sato
Y, Mori Y, Kato M, Sanada M, Morishima Y, Hosokawa K, Sasaki Y, Ohtake
S, Ogawa S, Nakao S. Frequent loss of HLA alleles associated with copy
number-neutral 6pLOH in acquired aplastic anemia. Blood. 2011. Prepublished
on 2011/10/04 as DOI 10.1182/blood-2011-07-365189.
16. Kao HW, M. S, Liang DC, Lai CL, Lee EH, Kuo MC, Lin TL, Shih
YS, Wu JH, Huang CF, Ogawa S, Shih LY. A high occurrence of acquisition
and/or expansion of c-CBL mutant clones in the progression of high-risk
myelodysplastic syndrome to acute myeloid leukemia. Neoplasia. 2011;in
press.
17. Iwakawa R, Kohno T, Kato M, Shiraishi K, Tsuta K, Noguchi
M, Ogawa S, Yokota J. MYC amplification as a prognostic marker of early-stage
lung adenocarcinoma identified by whole genome copy number analysis. Clinical
cancer research : an official journal of the American Association for
Cancer Research. 2011;17(6):1481-1489. Prepublished on 2010/12/15 as DOI
10.1158/1078-0432.CCR-10-2484.
18. Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb
KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum
FR, Riddell SR. Therapy of relapsed leukemia after allogeneic hematopoietic
cell transplantation with T cells specific for minor histocompatibility
antigens. Blood. 2010;115(19):3869-3878. Prepublished on 2010/01/15 as
DOI blood-2009-10-248997 [pii]
10.1182/blood-2009-10-248997.
19. Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio
N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S. Relapse of leukemia
with loss of mismatched HLA resulting from uniparental disomy after haploidentical
hematopoietic stem cell transplantation. Blood. 2010;115(15):3158-3161.
Prepublished on 2010/02/04 as DOI blood-2009-11-254284 [pii]
10.1182/blood-2009-11-254284.
20. Thoennissen NH, Krug UO, Lee DH, Kawamata N, Iwanski GB,
Lasho T, Weiss T, Nowak D, Koren-Michowitz M, Kato M, Sanada M, Shih LY,
Nagler A, Raynaud SD, Muller-Tidow C, Mesa R, Haferlach T, Gilliland DG,
Tefferi A, Ogawa S, Koeffler HP. Prevalence and prognostic impact of allelic
imbalances associated with leukemic transformation of Philadelphia chromosome-negative
myeloproliferative neoplasms. Blood. 2010;115(14):2882-2890. Prepublished
on 2010/01/14 as DOI blood-2009-07-235119 [pii]
10.1182/blood-2009-07-235119.
21. Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K,
Ohta M, Asaoka Y, Seto M, Imazeki F, Yoshida H, Ogawa S, Yokosuka O, Omata
M. Prognostic significance of genetic alterations detected by high-density
single nucleotide polymorphism array in gastric cancer. Cancer Sci. 2010;101(5):1261-1269.
Prepublished on 2010/03/25 as DOI CAS1500 [pii]
10.1111/j.1349-7006.2010.01500.x.
22. Shiba N, Kato M, Park MJ, Sanada M, Ito E, Fukushima K, Sako
M, Arakawa H, Ogawa S, Hayashi Y. CBL mutations in juvenile myelomonocytic
leukemia and pediatric myelodysplastic syndrome. Leukemia. 2010;24(5):1090-1092.
Prepublished on 2010/04/02 as DOI leu201049 [pii]
10.1038/leu.2010.49.
23. Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R,
Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M,
Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T,
Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards
S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett
D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves
M, Houlston RS. Variation in CDKN2A at 9p21.3 influences childhood acute
lymphoblastic leukemia risk. Nat Genet. 2010;42(6):492-494. Prepublished
on 2010/05/11 as DOI ng.585 [pii]
10.1038/ng.585.
24. Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M,
Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler
HP. Genomic profiling of adult acute lymphoblastic leukemia by single
nucleotide polymorphism oligonucleotide microarray and comparison to pediatric
acute lymphoblastic leukemia. Haematologica. 2010;95(9):1481-1488. Prepublished
on 2010/05/04 as DOI haematol.2009.011114 [pii]
10.3324/haematol.2009.011114.
25. Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler
HP, Sanada M. Deregulated Intracellular Signaling by Mutated c-CBL in
Myeloid Neoplasms. Clin Cancer Res. 2010;16(15):3825-3831. Prepublished
on 2010/06/16 as DOI 1078-0432.CCR-09-2341 [pii]
10.1158/1078-0432.CCR-09-2341.
26. Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H,
Koeffler HP. Gain-of-function c-CBL mutations associated with uniparental
disomy of 11q in myeloid neoplasms. Cell Cycle. 2010;9(6). Prepublished
on 2010/03/20 as DOI 11034 [pii].
27. Nowak D, Ogawa S, Muschen M, Kato M, Kawamata N, Meixel A,
Nowak V, Kim HS, Kang S, Paquette R, Chang MS, Thoenissen NH, Mossner
M, Hofmann WK, Kohlmann A, Weiss T, Haferlach T, Haferlach C, Koeffler
HP. SNP array analysis of tyrosine kinase inhibitor-resistant chronic
myeloid leukemia identifies heterogeneous secondary genomic alterations.
Blood. 2010;115(5):1049-1053. Prepublished on 2009/12/08 as DOI blood-2009-03-210377
[pii]
10.1182/blood-2009-03-210377.
28. Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida
T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa
M, Kitamura T, Chiba S. Hes1 immortalizes committed progenitors and plays
a role in blast crisis transition in chronic myelogenous leukemia. Blood.
2010;115(14):2872-2881. Prepublished on 2009/10/29 as DOI blood-2009-05-222836
[pii]
10.1182/blood-2009-05-222836.
29. Morishima S, Ogawa S, Matsubara A, Kawase T, Nannya Y, Kashiwase
K, Satake M, Saji H, Inoko H, Kato S, Kodera Y, Sasazuki T, Morishima
Y. Impact of highly conserved HLA haplotype on acute graft-versus-host
disease. Blood. 2010;115(23):4664-4670. Prepublished on 2010/03/26 as
DOI blood-2009-10-251157 [pii]
10.1182/blood-2009-10-251157.
30. Lilljebjorn H, Soneson C, Andersson A, Heldrup J, Behrendtz
M, Kawamata N, Ogawa S, Koeffler HP, Mitelman F, Johansson B, Fontes M,
Fioretos T. The correlation pattern of acquired copy number changes in
164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias. Hum Mol
Genet. 2010;19(16):3150-3158. Prepublished on 2010/06/02 as DOI ddq224
[pii]
10.1093/hmg/ddq224.
31. Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi
K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi
K, Kanai F, Ogawa S, Omata M, Koike K. Gastric cancer cell line Hs746T
harbors a splice site mutation of c-Met causing juxtamembrane domain deletion.
Biochem Biophys Res Commun. 2010;394(4):1042-1046. Prepublished on 2010/03/25
as DOI S0006-291X(10)00584-X [pii]
10.1016/j.bbrc.2010.03.120.
32. Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi
K, Takato T, Kurokawa M, Ogawa S, Chiba S. Derivation of functional mature
neutrophils from human embryonic stem cells. Blood. 2009;113(26):6584-6592.
Prepublished on 2009/03/27 as DOI blood-2008-06-160838 [pii]
10.1182/blood-2008-06-160838.
33. Yin D, Ogawa S, Kawamata N, Tunici P, Finocchiaro G, Eoli
M, Ruckert C, Huynh T, Liu G, Kato M, Sanada M, Jauch A, Dugas M, Black
KL, Koeffler HP. High-resolution genomic copy number profiling of glioblastoma
multiforme by single nucleotide polymorphism DNA microarray. Mol Cancer
Res. 2009;7(5):665-677. Prepublished on 2009/05/14 as DOI 1541-7786.MCR-08-0270
[pii]
10.1158/1541-7786.MCR-08-0270.
34. Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S,
Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita
J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y,
Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi
H, Koeffler HP, Ogawa S. Gain-of-function of mutated C-CBL tumour suppressor
in myeloid neoplasms. Nature. 2009;460:904-908. Prepublished on 2009/07/22
as DOI nature08240 [pii]
10.1038/nature08240.
35. Nowak D, Le Toriellec E, Stern MH, Kawamata N, Akagi T, Dyer
MJ, Hofmann WK, Ogawa S, Koeffler HP. Molecular allelokaryotyping of T-cell
prolymphocytic leukemia cells with high density single nucleotide polymorphism
arrays identifies novel common genomic lesions and acquired uniparental
disomy. Haematologica. 2009;94(4):518-527. Prepublished on 2009/03/13
as DOI haematol.2008.001347 [pii]
10.3324/haematol.2008.001347.
36. Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto
G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi
A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S. Gain-of-function
mutations and copy number increases of Notch2 in diffuse large B-cell
lymphoma. Cancer Sci. 2009;100(5):920-926. Prepublished on 2009/05/16
as DOI.
37. Kawase T, Matsuo K, Kashiwase K, Inoko H, Saji H, Ogawa S,
Kato S, Sasazuki T, Kodera Y, Morishima Y. HLA mismatch combinations associated
with decreased risk of relapse: implications for the molecular mechanism.
Blood. 2009;113(12):2851-2858. Prepublished on 2008/11/11 as DOI blood-2008-08-171934
[pii]
10.1182/blood-2008-08-171934.
38. Kawamata N, Zhang L, Ogawa S, Nannya Y, Dashti A, Lu D, Lim
S, Schreck R, Koeffler HP. Double minute chromosomes containing MYB gene
and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide
polymorphism DNA microarray and fluorescence in situ hybridization. Leuk
Res. 2009;33(4):569-571.
39. Kawamata N, Ogawa S, Seeger K, Kirschner-Schwabe R, Huynh
T, Chen J, Megrabian N, Harbott J, Zimmermann M, Henze G, Schrappe M,
Bartram CR, Koeffler HP. Molecular allelokaryotyping of relapsed pediatric
acute lymphoblastic leukemia. Int J Oncol. 2009;34(6):1603-1612. Prepublished
on 2009/05/09 as DOI.
40. Kawamata N, Ogawa S, Gueller S, Ross SH, Huynh T, Chen J,
Chang A, Nabavi-Nouis S, Megrabian N, Siebert R, Martinez-Climent JA,
Koeffler HP. Identified hidden genomic changes in mantle cell lymphoma
using high-resolution single nucleotide polymorphism genomic array. Exp
Hematol. 2009;37(8):937-946. Prepublished on 2009/05/30 as DOI S0301-472X(09)00175-1
[pii]
10.1016/j.exphem.2009.04.012.
41. Kato M, Takita J, Takahashi K, Mimaki M, Chen Y, Koh K, Ida
K, Oka A, Mizuguchi M, Ogawa S, Igarashi T. Hepatoblastoma in a patient
with sotos syndrome. J Pediatr. 2009;155(6):937-939. Prepublished on 2009/11/17
as DOI S0022-3476(09)00608-8 [pii]
10.1016/j.jpeds.2009.06.039.
42. Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa
A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka
Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa
Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi
Y, Ogawa S. Frequent inactivation of A20 in B-cell lymphomas. Nature.
2009;459(7247):712-716. Prepublished on 2009/05/05 as DOI nature07969
[pii]
10.1038/nature07969.
43. Kamei M, Nannya Y, Torikai H, Kawase T, Taura K, Inamoto
Y, Takahashi T, Yazaki M, Morishima S, Tsujimura K, Miyamura K, Ito T,
Togari H, Riddell SR, Kodera Y, Morishima Y, Kuzushima K, Ogawa S, Akatsuka
Y. HapMap scanning of novel human minor histocompatibility antigens. Blood.
2009;113(21):5041-5048. Prepublished on 2008/09/24 as DOI blood-2008-07-171678
[pii]
10.1182/blood-2008-07-171678.
44. Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto
A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi
K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M,
Ogawa S, Chiba S. Notch activation induces the generation of functional
NK cells from human cord blood CD34-positive cells devoid of IL-15. J
Immunol. 2009;182(10):6168-6178. Prepublished on 2009/05/06 as DOI 182/10/6168
[pii]
10.4049/jimmunol.0803036.
45. Akagi T, Shih LY, Ogawa S, Gerss J, Moore SR, Schreck R,
Kawamata N, Liang DC, Sanada M, Nannya Y, Deneberg S, Zachariadis V, Nordgren
A, Song JH, Dugas M, Lehmann S, Koeffler HP. Single nucleotide polymorphism
genomic arrays analysis of t(8;21) acute myeloid leukemia cells. Haematologica.
2009;94(9):1301-1306. Prepublished on 2009/09/08 as DOI 94/9/1301 [pii]
10.3324/haematol.2009.005744.
46. Akagi T, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada
M, Okamoto R, Miller CW, Liang DC, Ogawa S, Koeffler HP. Hidden abnormalities
and novel classification of t(15;17) acute promyelocytic leukemia (APL)
based on genomic alterations. Blood. 2009;113(8):1741-1748. Prepublished
on 2008/12/26 as DOI blood-2007-12-130260 [pii]
10.1182/blood-2007-12-130260.
47. Akagi T, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G,
Olaru A, Kawamata N, Boult J, Soukiasian HJ, Miller CW, Ogawa S, Meltzer
SJ, Koeffler HP. Chromosomal abnormalities and novel disease-related regions
in progression from Barrett's esophagus to esophageal adenocarcinoma.
Int J Cancer. 2009;125(10):2349-2359. Prepublished on 2009/08/12 as DOI
10.1002/ijc.24620.
48. Yabe T, Matsuo K, Hirayasu K, Kashiwase K, Kawamura-Ishii
S, Tanaka H, Ogawa A, Takanashi M, Satake M, Nakajima K, Tokunaga K, Inoko
H, Saji H, Ogawa S, Juji T, Sasazuki T, Kodera Y, Morishima Y. Donor killer
immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand
combination and antithymocyte globulin preadministration are critical
factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated
bone marrow transplantation. Biol Blood Marrow Transplant. 2008;14(1):75-87.
Prepublished on 2007/12/27 as DOI S1083-8791(07)00489-2 [pii]
10.1016/j.bbmt.2007.09.012.
49. Walsh CS, Ogawa S, Scoles DR, Miller CW, Kawamata N, Narod
SA, Koeffler HP, Karlan BY. Genome-wide loss of heterozygosity and uniparental
disomy in BRCA1/2-associated ovarian carcinomas. Clin Cancer Res. 2008;14(23):7645-7651.
Prepublished on 2008/12/03 as DOI 14/23/7645 [pii]
10.1158/1078-0432.CCR-08-1291.
50. Walsh CS, Ogawa S, Karahashi H, Scoles DR, Pavelka JC, Tran
H, Miller CW, Kawamata N, Ginther C, Dering J, Sanada M, Nannya Y, Slamon
DJ, Koeffler HP, Karlan BY. ERCC5 is a novel biomarker of ovarian cancer
prognosis. J Clin Oncol. 2008;26(18):2952-2958.
51. Tanaka Y, Kanai F, Tada M, Tateishi R, Sanada M, Nannya Y,
Ohta M, Asaoka Y, Seto M, Shiina S, Yoshida H, Kawabe T, Yokosuka O, Ogawa
S, Omata M. Gain of GRHL2 is associated with early recurrence of hepatocellular
carcinoma. J Hepatol. 2008;49(5):746-757.
52. Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa
S, Chiba S, Kurokawa M. AML1-Evi-1 specifically transforms hematopoietic
stem cells through fusion of the entire Evi-1 sequence to AML1. Leukemia.
2008.
53. Suzuki M, Kato M, Yuyan C, Takita J, Sanada M, Nannya Y,
Yamamoto G, Takahashi A, Ikeda H, Kuwano H, Ogawa S, Hayashi Y. Whole-genome
profiling of chromosomal aberrations in hepatoblastoma using high-density
single-nucleotide polymorphism genotyping microarrays. Cancer Sci. 2008;99(3):564-570.
54. Shinmura K, Suzuki M, Yamada H, Tao H, Goto M, Kamo T, Nagura
K, Kageyama S, Kato M, Ogawa S, Maekawa M, Takamochi K, Suzuki K, Nakamura
T, Sugimura H. Characterization of adenocarcinoma of the lung in a familial
adenomatous polyposis patient. Pathol Int. 2008;58(11):706-712. Prepublished
on 2008/10/11 as DOI PIN2297 [pii]
10.1111/j.1440-1827.2008.02297.x.
55. Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano
K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S. Coordinated regulation of
transcription factors through Notch2 is an important mediator of mast
cell fate. Proc Natl Acad Sci U S A. 2008;105(22):7839-7844.
56. Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato
M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E,
Inoko H, Morishima Y, Kodera Y, Takehiko S. Exploration of the genetic
basis of GVHD by genetic association studies. Biol Blood Marrow Transplant.
2008;15(1 Suppl):39-41. Prepublished on 2009/01/29 as DOI S1083-8791(08)00572-7
[pii]
10.1016/j.bbmt.2008.11.020.
57. Lin LJ, Asaoka Y, Tada M, Sanada M, Nannya Y, Tanaka Y, Tateishi
K, Ohta M, Seto M, Sasahira N, Kawabe T, Zheng CQ, Kanai F, Ogawa S, Omata
M. Integrated analysis of copy number alterations and loss of heterozygosity
in human pancreatic cancer using a high-resolution, single nucleotide
polymorphism array. Oncology. 2008;75(1-2):102-112. Prepublished on 2008/09/13
as DOI 000155813 [pii]
10.1159/000155813.
58. Lehmann S, Ogawa S, Raynaud SD, Sanada M, Nannya Y, Ticchioni
M, Bastard C, Kawamata N, Koeffler HP. Molecular allelokaryotyping of
early-stage, untreated chronic lymphocytic leukemia. Cancer. 2008;112(6):1296-1305.
59. Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto
M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both
Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
Pigment Cell Research. 2008.
60. Kawase T, Nannya Y, Torikai H, Yamamoto G, Onizuka M, Morishima
S, Tsujimura K, Miyamura K, Kodera Y, Morishima Y, Takahashi T, Kuzushima
K, Ogawa S, Akatsuka Y. Identification of human minor histocompatibility
antigens based on genetic association with highly parallel genotyping
of pooled DNA. Blood. 2008;111(6):3286-3294. Prepublished on 2008/01/08
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61. Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C,
Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller
CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler
HP. Cloning of genes involved in chromosomal translocations by high-resolution
single nucleotide polymorphism genomic microarray. Proc Natl Acad Sci
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62. Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, Hemminki
K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig
WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP. Molecular allelokaryotyping
of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide
polymorphism oligonucleotide genomic microarray. Blood. 2008;111(2):776-784.
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63. Kawamata N, Ogawa S, Yamamoto G, Lehmann S, Levine RL, Pikman
Y, Nannya Y, Sanada M, Miller CW, Gilliland DG, Koeffler HP. Genetic profiling
of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide
microarray. Exp Hematol. 2008;36(11):1471-1479.
64. Kawamata N, Dashti A, Lu D, Miller B, Koeffler HP, Schreck
R, Moore S, Ogawa S. Chronic phase of ETV6-ABL1 positive CML responds
to imatinib. Genes Chromosomes Cancer. 2008;47(10):919-921.
65. Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita
M, Chiba S, Ogawa S, Kurokawa M. AML1/Runx1 Negatively Regulates Quiescent
Hematopoietic Stem Cells in Adult Hematopoiesis. J Immunol. 2008;180(7):4402-4408.
66. Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa
S, Chiba S, Kurokawa M. Evi-1 is a critical regulator for hematopoietic
stem cells and transformed leukemic cells. Cell Stem Cell. 2008;3(2):207-220.
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10.1016/j.stem.2008.06.002.
67. Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang
L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa
S. Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008;455(7215):971-974.
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10.1038/nature07399.
68. Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya
Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C,
Koeffler HP. Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic
syndrome with normal karyotype. Haematologica. 2008;94:213-223. Prepublished
on 2009/01/16 as DOI haematol.13024 [pii]
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69. Yamamoto G, Nannya Y, Kato M, Sanada M, Levine RL, Kawamata
N, Hangaishi A, Kurokawa M, Chiba S, Gilliland DG, Koeffler HP, Ogawa
S. Highly sensitive method for genomewide detection of allelic composition
in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism
genotyping microarrays. Am J Hum Genet. 2007;81(1):114-126.
70. Sanada M, Uike N, Ohyashiki K, Ozawa K, Lili W, Hangaishi
A, Kanda Y, Chiba S, Kurokawa M, Omine M, Mitani K, Ogawa S. Unbalanced
translocation der(1;7)(q10;p10) defines a unique clinicopathological subgroup
of myeloid neoplasms. Leukemia. 2007;21(5):992-997.
71. Nannya Y, Taura K, Kurokawa M, Chiba S, Ogawa S. Evaluation
of genome-wide power of genetic association studies based on empirical
data from the HapMap project. Hum Mol Genet. 2007;16(20):3494-3505.
72. Morishima Y, Yabe T, Matsuo K, Kashiwase K, Inoko H, Saji
H, Yamamoto K, Maruya E, Akatsuka Y, Onizuka M, Sakamaki H, Sao H, Ogawa
S, Kato S, Juji T, Sasazuki T, Kodera Y. Effects of HLA allele and killer
immunoglobulin-like receptor ligand matching on clinical outcome in leukemia
patients undergoing transplantation with T-cell-replete marrow from an
unrelated donor. Biol Blood Marrow Transplant. 2007;13(3):315-328.
73. Matsumoto A, Haraguchi K, Takahashi T, Azuma T, Kanda Y,
Tomita K, Kurokawa M, Ogawa S, Takahashi K, Chiba S, Kitamura T. Immunotherapy
against metastatic renal cell carcinoma with mature dendritic cells. Int
J Urol. 2007;14(4):277-283.
74. Lips EH, de Graaf EJ, Tollenaar RA, van Eijk R, Oosting J,
Szuhai K, Karsten T, Nanya Y, Ogawa S, van de Velde CJ, Eilers PH, van
Wezel T, Morreau H. Single nucleotide polymorphism array analysis of chromosomal
instability patterns discriminates rectal adenomas from carcinomas. J
Pathol. 2007;212(3):269-277.
75. Kawazu M, Yamamoto G, Yoshimi M, Yamamoto K, Asai T, Ichikawa
M, Seo S, Nakagawa M, Chiba S, Kurokawa M, Ogawa S. Expression profiling
of immature thymocytes revealed a novel homeobox gene that regulates double-negative
thymocyte development. J Immunol. 2007;179(8):5335-5345.
76. Kawase T, Akatsuka Y, Torikai H, Morishima S, Oka A, Tsujimura
A, Miyazaki M, Tsujimura K, Miyamura K, Ogawa S, Inoko H, Morishima Y,
Kodera Y, Kuzushima K, Takahashi T. Alternative splicing due to an intronic
SNP in HMSD generates a novel minor histocompatibility antigen. Blood.
2007;110(3):1055-1063.
77. Jacobs S, Thompson ER, Nannya Y, Yamamoto G, Pillai R, Ogawa
S, Bailey DK, Campbell IG. Genome-wide, high-resolution detection of copy
number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded
tumor tissue using microarrays. Cancer Res. 2007;67(6):2544-2551.
78. Suzuki T, Yokoyama Y, Kumano K, Takanashi M, Kozuma S, Takato
T, Nakahata T, Nishikawa M, Sakano S, Kurokawa M, Ogawa S, Chiba S. Highly
efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc
chimeric protein. Stem Cells. 2006;24(11):2456-2465.
79. Oshima K, Kanda Y, Nakahara F, Shoda E, Suzuki T, Imai Y,
Watanabe T, Asai T, Izutsu K, Ogawa S, Motokura T, Chiba S, Kurokawa M.
Pharmacokinetics of alemtuzumab after haploidentical HLA-mismatched hematopoietic
stem cell transplantation using in vivo alemtuzumab with or without CD52-positive
malignancies. Am J Hematol. 2006;81(11):875-879.
80. Nishiyama U, Yoshino T, Ozai M, Yoshioka R, Fujisawa M, Ogasawara
Y, Kitahori M, Yoshioka E, Kubo K, Komeno Y, Kurokawa M, Ogawa S, Chiba
S, Osawa T, Kuwaki T, Hirai H, Miwa A. Antineoplastic effect of a single
oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic
cells harboring Flt3-activating mutations. Leuk Res. 2006;30(12):1541-1546.
81. Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai
T, Ogawa S, Kurokawa M, Chiba S. AML1/Runx1 rescues Notch1-null mutation-induced
deficiency of para-aortic splanchnopleural hematopoiesis. Blood. 2006;108(10):3329-3334.
82. Kusama M, Kubota T, Matsukura Y, Matsuno K, Ogawa S, Kanda
Y, Iga T. Influence of glutathione S-transferase A1 polymorphism on the
pharmacokinetics of busulfan. Clin Chim Acta. 2006;368(1-2):93-98.
83. Hosoya N, Sanada M, Nannya Y, Nakazaki K, Wang L, Hangaishi
A, Kurokawa M, Chiba S, Ogawa S. Genomewide screening of DNA copy number
changes in chronic myelogenous leukemia with the use of high-resolution
array-based comparative genomic hybridization. Genes Chromosomes Cancer.
2006;45(5):482-494.
84. Haraguchi K, Takahashi T, Nakahara F, Matsumoto A, Kurokawa
M, Ogawa S, Oda H, Hirai H, Chiba S. CD1d expression level in tumor cells
is an important determinant for anti-tumor immunity by natural killer
T cells. Leuk Lymphoma. 2006;47(10):2218-2223.
85. Seo S, Asai T, Saito T, Suzuki T, Morishita Y, Nakamoto T,
Ichikawa M, Yamamoto G, Kawazu M, Yamagata T, Sakai R, Mitani K, Ogawa
S, Kurokawa M, Chiba S, Hirai H. Crk-associated substrate lymphocyte type
is required for lymphocyte trafficking and marginal zone B cell maintenance.
J Immunol. 2005;175(6):3492-3501.
86. Oshima K, Sakata-Yanagimoto M, Asano-Mori Y, Izutsu K, Watanabe
T, Shoda E, Ogawa S, Motokura T, Chiba S, Kurokawa M, Hirai H, Kanda Y.
Cardiac complications after haploidentical HLA-mismatched hematopoietic
stem cell transplantation using in vivo alemtuzumab. Bone Marrow Transplant.
2005;36(9):821-824.
87. Nitta E, Izutsu K, Yamaguchi Y, Imai Y, Ogawa S, Chiba S,
Kurokawa M, Hirai H. Oligomerization of Evi-1 regulated by the PR domain
contributes to recruitment of corepressor CtBP. Oncogene. 2005;24(40):6165-6173.
88. Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi
A, Kurokawa M, Chiba S, Bailey DK, Kennedy GC, Ogawa S. A robust algorithm
for copy number detection using high-density oligonucleotide single nucleotide
polymorphism genotyping arrays. Cancer Res. 2005;65(14):6071-6079.
89. Masuda S, Kumano K, Shimizu K, Imai Y, Kurokawa M, Ogawa
S, Miyagishi M, Taira K, Hirai H, Chiba S. Notch1 oncoprotein antagonizes
TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator
p300. Cancer Sci. 2005;96(5):274-282.
90. Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki
K, Kurokawa M, Hayashi Y, Ogawa S, Chiba S. Mutations of the Notch1 gene
in T-cell acute lymphoblastic leukemia: analysis in adults and children.
Leukemia. 2005;19(10):1841-1843.
91. Kunisato A, Ogawa S, Chiba S. Dominant-negative activity
of stem cell leukemia (SCL) lacking bHLH domain. Blood. 2005.
92. Komeno Y, Kurokawa M, Imai Y, Takeshita M, Matsumura T, Kubo
K, Yoshino T, Nishiyama U, Kuwaki T, Kubo K, Osawa T, Ogawa S, Chiba S,
Miwa A, Hirai H. Identification of Ki23819, a highly potent inhibitor
of kinase activity of mutant FLT3 receptor tyrosine kinase. Leukemia.
2005;19(6):930-935.
93. Kawazu M, Asai T, Ichikawa M, Yamamoto G, Saito T, Goyama
S, Mitani K, Miyazono K, Chiba S, Ogawa S, Kurokawa M, Hirai H. Functional
domains of Runx1 are differentially required for CD4 repression, TCRbeta
expression, and CD4/8 double-negative to CD4/8 double-positive transition
in thymocyte development. J Immunol. 2005;174(6):3526-3533.
94. Kanda Y, Oshima K, Asano-Mori Y, Kandabashi K, Nakagawa M,
Sakata-Yanagimoto M, Izutsu K, Hangaishi A, Tsujino S, Ogawa S, Motokura
T, Chiba S, Hirai H. In vivo alemtuzumab enables haploidentical human
leukocyte antigen-mismatched hematopoietic stem-cell transplantation without
ex vivo graft manipulation. Transplantation. 2005;79(10):1351-1357.
95. Kanda Y, Komatsu Y, Akahane M, Kojima S, Asano-Mori Y, Tada
M, Oshima K, Isayama H, Ogawa S, Motokura T, Chiba S, Ohtomo K, Omata
M, Hirai H. Graft-versus-tumor effect against advanced pancreatic cancer
after allogeneic reduced-intensity stem cell transplantation. Transplantation.
2005;79(7):821-827.
96. Ito Y, Ohyashiki K, Hirai H, Ogawa S, Mitani K, Hotta T,
Bessho M, Naoe T, Mizoguchi H, Uchiyama T, Omine M. Assessment of the
international prognostic scoring system for determining chemotherapeutic
indications in myelodysplastic syndrome: Japanese retrospective multicenter
study. Int J Hematol. 2005;82(3):236-242.
97. Hosoya N, Qiao Y, Hangaishi A, Wang L, Nannya Y, Sanada M,
Kurokawa M, Chiba S, Hirai H, Ogawa S. Identification of a SRC-like tyrosine
kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous
leukemia carrying a t(6;12)(q21;p13) translocation. Genes Chromosomes
Cancer. 2005;42(3):269-279.
98. Hori A, Kanda Y, Goyama S, Onishi Y, Komeno Y, Mitani K,
Kishi Y, Ogawa S, Imataki O, Chiba S, Kojima R, Hamaki T, Sakiyama M,
Kami M, Makimoto A, Tanosaki R, Takaue Y, Hirai H. A prospective trial
to evaluate the safety and efficacy of pravastatin for the treatment of
refractory chronic graft-versus-host disease. Transplantation. 2005;79(3):372-374.
99. Haraguchi K, Takahashi T, Matsumoto A, Asai T, Kanda Y, Kurokawa
M, Ogawa S, Oda H, Taniguchi M, Hirai H, Chiba S. Host-residual invariant
NK T cells attenuate graft-versus-host immunity. J Immunol. 2005;175(2):1320-1328.
100. Crcareva A, Saito T, Kunisato A, Kumano K, Suzuki T, Sakata-Yanagimoto
M, Kawazu M, Stojanovic A, Kurokawa M, Ogawa S, Hirai H, Chiba S. Hematopoietic
stem cells expanded by fibroblast growth factor-1 are excellent targets
for retrovirus-mediated gene delivery. Exp Hematol. 2005;33(12):1459-1469.
101. Yamaguchi Y, Kurokawa M, Imai Y, Izutsu K, Asai T, Ichikawa
M, Yamamoto G, Nitta E, Yamagata T, Sasaki K, Mitani K, Ogawa S, Chiba
S, Hirai H. AML1 is functionally regulated through p300-mediated acetylation
on specific lysine residues. J Biol Chem. 2004;279(15):15630-15638.
102. Sakata-Yanagimoto M, Kanda Y, Nakagawa M, Asano-Mori Y,
Kandabashi K, Izutsu K, Imai Y, Hangaishi A, Kurokawa M, Tsujino S, Ogawa
S, Chiba S, Motokura T, Hirai H. Predictors for severe cardiac complications
after hematopoietic stem cell transplantation. Bone Marrow Transplant.
2004;33(10):1043-1047.
103. Ogawa N, Kanda Y, Matsubara M, Asano Y, Nakagawa M, Sakata-Yanagimoto
M, Kandabashi K, Izutsu K, Imai Y, Hangaishi A, Kurokawa M, Tsujino S,
Ogawa S, Aoki K, Chiba S, Motokura T, Hirai H. Increased incidence of
acute graft-versus-host disease with the continuous infusion of cyclosporine
A compared to twice-daily infusion. Bone Marrow Transplant. 2004;33(5):549-552.
104. Kawazu M, Kanda Y, Nannya Y, Aoki K, Kurokawa M, Chiba S,
Motokura T, Hirai H, Ogawa S. Prospective comparison of the diagnostic
potential of real-time PCR, double-sandwich enzyme-linked immunosorbent
assay for galactomannan, and a (1-->3)-beta-D-glucan
test in weekly screening for invasive aspergillosis in patients with hematological
disorders. J Clin Microbiol. 2004;42(6):2733-2741.
105. Ichikawa M, Asai T, Saito T, Seo S, Yamazaki I, Yamagata
T, Mitani K, Chiba S, Ogawa S, Kurokawa M, Hirai H. AML-1 is required
for megakaryocytic maturation and lymphocytic differentiation, but not
for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat
Med. 2004;10(3):299-304.
106. Ichikawa M, Asai T, Chiba S, Kurokawa M, Ogawa S. Runx1/AML-1
ranks as a master regulator of adult hematopoiesis. Cell Cycle. 2004;3(6):722-724.
107. Haraguchi K, Takahashi T, Hiruma K, Kanda Y, Tanaka Y, Ogawa
S, Chiba S, Miura O, Sakamaki H, Hirai H. Recovery of Valpha24+ NKT cells
after hematopoietic stem cell transplantation. Bone Marrow Transplant.
2004;34(7):595-602.
108. Goyama S, Yamaguchi Y, Imai Y, Kawazu M, Nakagawa M, Asai
T, Kumano K, Mitani K, Ogawa S, Chiba S, Kurokawa M, Hirai H. The transcriptionally
active form of AML1 is required for hematopoietic rescue of the AML1-deficient
embryonic para-aortic splanchnopleural (P-Sp) region. Blood. 2004;104(12):3558-3564.
109. Goyama S, Kanda Y, Nannya Y, Ogawa S, Asano-Moki Y, Ogawa
N, Nakagawa M, Sakata-Yanagimoto M, Kawazu M, Komeno Y, Imai Y, Hangaishi
A, Kurokawa M, Tsujino S, Aoki K, Chiba S, Motokura T, Hirai H. Clinical
significance of peripheral blood erythroblastosis after hematopoietic
stem cell transplantation. Leuk Lymphoma. 2004;45(12):2439-2443.
110. Endo-Matsubara M, Ogawa S, Sasaki K, Takahashi T, Chiba
S, Hirai H. Immature granulocyte fraction in the peripheral blood is a
practical indicator for mobilization of CD34(+) cells. Am J Hematol. 2004;77(3):223-228.
111. Yamamoto T, Nagafuchi N, Ozeki T, Kubota T, Ishikawa H,
Ogawa S, Yamada Y, Hirai H, Iga T. CYP3A4*18: it is not rare allele in
Japanese population. Drug Metab Pharmacokinet. 2003;18(4):267-268.
112. Wang L, Ogawa S, Hangaishi A, Qiao Y, Hosoya N, Nanya Y,
Ohyashiki K, Mizoguchi H, Hirai H. Molecular characterization of the recurrent
unbalanced translocation der(1;7)(q10;p10). Blood. 2003;102(7):2597-2604.
113. Qiao Y, Ogawa S, Hangaishi A, Yuji K, Izutsu K, Kunisato
A, Imai Y, Wang L, Hosoya N, Nannya Y, Sato Y, Maki K, Mitani K, Hirai
H. Identification of a novel fusion gene, TTL, fused to ETV6 in acute
lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in
leukemogenesis. Leukemia. 2003;17(6):1112-1120.
114. Nakamura F, Ogawa S, Izutsu K, Imai Y, Maki K, Yamagata
T, Mitani K, Hirai H. Should young patients with e19a2 type BCR/ABL rearrangement
undergo stem cell transplantation? Leuk Lymphoma. 2003;44(2):381-382.
115. Kumano K, Chiba S, Kunisato A, Sata M, Saito T, Nakagami-Yamaguchi
E, Yamaguchi T, Masuda S, Shimizu K, Takahashi T, Ogawa S, Hamada Y, Hirai
H. Notch1 but not Notch2 is essential for generating hematopoietic stem
cells from endothelial cells. Immunity. 2003;18(5):699-711.
116. Komeno Y, Ogawa S, Ishida T, Takeuchi K, Tsujino S, Kurokawa
M, Aoki K, Kanda Y, Chiba S, Motokura T, Fukayama M, Hirai H. Ischemic
colitis as a manifestation of thrombotic microangiopathy following bone
marrow transplantation. Intern Med. 2003;42(12):1228-1232.
117. Komeno Y, Kanda Y, Kandabashi K, Kawazu M, Goyama S, Takeshita
M, Nannya Y, Niino M, Nakamoto T, Kurokawa M, Tsujino S, Ogawa S, Aoki
K, Chiba S, Motokura T, Hirai H. Reduced-intensity bone marrow transplantation
from an alternative unrelated donor for myelodysplastic syndrome of first-donor
origin. Am J Hematol. 2003;72(3):220-222.
118. Kawazu M, Kanda Y, Goyama S, Takeshita M, Nannya Y, Niino
M, Komeno Y, Nakamoto T, Kurokawa M, Tsujino S, Ogawa S, Aoki K, Chiba
S, Motokura T, Ohishi N, Hirai H. Rapid diagnosis of invasive pulmonary
aspergillosis by quantitative polymerase chain reaction using bronchial
lavage fluid. Am J Hematol. 2003;72(1):27-30.
119. Hosoya N, Ogawa S, Motokura T, Hangaishi A, Wang L, Qiao
Y, Nannya Y, Kogi M, Hirai H. Molecular cytogenetic analyses of HIG, a
novel human cell line carrying t(1;3)(p36.3;q25.3) established from a
patient with chronic myelogenous leukemia in blastic crisis. Int J Hematol.
2003;78(5):432-438.
120. Asano Y, Kanda Y, Ogawa N, Sakata-Yanagimoto M, Nakagawa
M, Kawazu M, Goyama S, Kandabashi K, Izutsu K, Imai Y, Hangaishi A, Kurokawa
M, Tsujino S, Ogawa S, Aoki K, Chiba S, Motokura T, Hirai H. Male predominance
among Japanese adult patients with late-onset hemorrhagic cystitis after
hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003;32(12):1175-1179.
121. Tsurumi S, Nakamura Y, Maki K, Omine M, Fujita K, Okamura
T, Niho Y, Hashimoto S, Kanno K, Suzuki K, Hangaishi A, Ogawa S, Hirai
H, Mitani K. N-ras and p53 gene mutations in Japanese patients with myeloproliferative
disorders. Am J Hematol. 2002;71(2):131-133.
122. Tanaka Y, Takahashi T, Nieda M, Masuda S, Kashiwase K, Takahashi
T, Ogawa S, Chiba S, Juji T, Hirai H. Generation of Fas-independent CD4+
cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide.
Leuk Res. 2002;26(3):317-321.
123. Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana
K, Morimoto C, Hirai H. MICAL, a novel CasL interacting molecule, associates
with vimentin. J Biol Chem. 2002;277(17):14933-14941.
124. Imai O, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa
S, Chiba S, Mitani K, Hirai H. Mutational analyses of the AML1 gene in
patients with myelodysplastic syndrome. Leuk Lymphoma. 2002;43(3):617-621.
125. Hangaishi A, Ogawa S, Qiao Y, Wang L, Hosoya N, Yuji K,
Imai Y, Takeuchi K, Miyawaki S, Hirai H. Mutations of Chk2 in primary
hematopoietic neoplasms. Blood. 2002;99(8):3075-3077.
126. Goyama S, Kanda Y, Nannya Y, Kawazu M, Takeshita M, Niino
M, Komeno Y, Nakamoto T, Kurokawa M, Tsujino S, Ogawa S, Aoki K, Chiba
S, Motokura T, Shiratori Y, Hirai H. Reverse seroconversion of hepatitis
B virus after hematopoietic stem cell transplantation. Leuk Lymphoma.
2002;43(11):2159-2163.
127. Chiba S, Saito A, Ogawa S, Takeuchi K, Kumano K, Seo S,
Suzuki T, Tanaka Y, Saito T, Izutsu K, Yuji K, Masuda S, Futami S, Nishida
M, Suzuki G, Gale RP, Fukayama M, Maekawa K, Hirai H. Transplantation
for accidental acute high-dose total body neutron- and gamma-radiation
exposure. Bone Marrow Transplant. 2002;29(11):935-939.
128. Kami M, Fukui T, Ogawa S, Kazuyama Y, Machida U, Tanaka
Y, Kanda Y, Kashima T, Yamazaki Y, Hamaki T, Mori S, Akiyama H, Mutou
Y, Sakamaki H, Osumi K, Kimura S, Hirai H. Use of real-time PCR on blood
samples for diagnosis of invasive aspergillosis. Clin Infect Dis. 2001;33(9):1504-1512.
129. Imai Y, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa
S, Chiba S, Mitani K, Hirai H. Mutations of the Smad4 gene in acute myelogeneous
leukemia and their functional implications in leukemogenesis. Oncogene.
2001;20(1):88-96.
130. Tanaka Y, Takahashi T, Nieda M, Masuda S, Kashiwase K, Ogawa
S, Chiba S, Juji T, Hirai H. Generation of HLA-DRB1*1501-restricted p190
minor bcr-abl (e1a2)-specific CD4+ T lymphocytes. Br J Haematol. 2000;109(2):435-437.
131. Tanaka Y, Kami M, Ogawa S, Machida U, Takahashi T, Ichikawa
M, Yuji K, Izutsu K, Asai T, Kanda Y, Honda H, Mitani K, Chiba S, Hirai
H, Yazaki Y, Sasaki M, Sasaki K, Mineishi S. Hyperacute graft-versus-host
disease and NKT cells. Am J Hematol. 2000;63(1):60-61.
132. Nakamoto T, Yamagata T, Sakai R, Ogawa S, Honda H, Ueno
H, Hirano N, Yazaki Y, Hirai H. CIZ, a zinc finger protein that interacts
with p130(cas) and activates the expression of matrix metalloproteinases.
Mol Cell Biol. 2000;20(5):1649-1658.
133. Machida U, Kami M, Fukui T, Kazuyama Y, Kinoshita M, Tanaka
Y, Kanda Y, Ogawa S, Honda H, Chiba S, Mitani K, Muto Y, Osumi K, Kimura
S, Hirai H. Real-time automated PCR for early diagnosis and monitoring
of cytomegalovirus infection after bone marrow transplantation. J Clin
Microbiol. 2000;38(7):2536-2542.
134. Kurokawa M, Mitani K, Yamagata T, Takahashi T, Izutsu K,
Ogawa S, Moriguchi T, Nishida E, Yazaki Y, Hirai H. The evi-1 oncoprotein
inhibits c-Jun N-terminal kinase and prevents stress-induced cell death.
Embo J. 2000;19(12):2958-2968.
135. Kami M, Tanaka Y, Kanda Y, Ogawa S, Masumoto T, Ohtomo K,
Matsumura T, Saito T, Machida U, Kashima T, Hirai H. Computed tomographic
scan of the chest, latex agglutination test and plasma (1AE3)-beta-D-glucan
assay in early diagnosis of invasive pulmonary aspergillosis: a prospective
study of 215 patients. Haematologica. 2000;85(7):745-752.
136. Imai Y, Kurokawa M, Izutsu K, Hangaishi A, Takeuchi K, Maki
K, Ogawa S, Chiba S, Mitani K, Hirai H. Mutations of the AML1 gene in
myelodysplastic syndrome and their functional implications in leukemogenesis.
Blood. 2000;96(9):3154-3160.
137. Kanda Y, Tanaka Y, Kami M, Saito T, Asai T, Izutsu K, Yuji
K, Ogawa S, Honda H, Mitani K, Chiba S, Yazaki Y, Hirai H. TT virus in
bone marrow transplant recipients. Blood. 1999;93(8):2485-2490.
138. Kanda Y, Chiba S, Tanaka Y, Kami M, Saito T, Izutsu K, Asai
T, Yuji K, Ogawa S, Honda H, Mitani K, Usuki K, Urabe A, Shirakawa K,
Yatomi T, Nakamura N, Yazaki Y, Hirai H. Increased serum soluble Fas ligand
associated with recurrent B-cell non-Hodgkin's lymphoma after autologous
peripheral blood stem cell transplantation. Leuk Lymphoma. 1999;34(5-6):625-628.
139. Kanda Y, Chiba S, Tanaka Y, Kami M, Saito T, Asai T, Izutsu
K, Yuji K, Ogawa S, Honda H, Mitani K, Yazaki Y, Hirai H. TT virus in
frequently transfused patients. Am J Med. 1999;106(1):116-117.
140. Kami M, Shirouzu I, Mitani K, Ogawa S, Matsumura T, Kanda
Y, Masumoto T, Saito T, Tanaka Y, Maki K, Honda H, Chiba S, Ohtomo K,
Hirai H, Yazaki Y. Early diagnosis of central nervous system aspergillosis
with combination use of cerebral diffusion-weighted echo-planar magnetic
resonance image and polymerase chain reaction of cerebrospinal fluid.
Intern Med. 1999;38(1):45-48.
141. Kami M, Ogawa S, Kanda Y, Tanaka Y, Machida U, Matsumura
T, Sakamaki H, Hirai H. Early diagnosis of central nervous system aspergillosis
using polymerase chain reaction, latex agglutination test, and enzyme-linked
immunosorbent assay. Br J Haematol. 1999;106(2):536-537.
142. Kami M, Matsukura A, Kanda Y, Ogawa S, Makuuchi M, Hirai
H. Intramural hematoma of stomach after splenectomy for idiopathic thrombocytopenic
purpura. Haematologica. 1999;84(7):669-671.
143. Kami M, Kanda Y, Ogawa S, Mori S, Tanaka Y, Honda H, Chiba
S, Mitani K, Yazaki Y, Hirai H. Frequent false-positive results of Aspergillus
latex agglutination test: transient Aspergillus antigenemia during neutropenia.
Cancer. 1999;86(2):274-281.
144. Hirai H, Ogawa S, Kurokawa M, Yazaki Y, Mitani K. Molecular
characterization of the genomic breakpoints in a case of t(3;21)(q26;q22).
Genes Chromosomes Cancer. 1999;26(1):92-96.
145. Tanaka K, Tanaka T, Kurokawa M, Imai Y, Ogawa S, Mitani
K, Yazaki Y, Hirai H. The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated
chimeric oncoproteins accumulate PEBP2beta(CBFbeta) in the nucleus more
efficiently than wild-type AML1. Blood. 1998;91(5):1688-1699.
146. Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks
transforming growth factor-beta-mediated growth inhibition of myeloid
cells. Blood. 1998;92(11):4003-4012.
147. Kanda Y, Tanaka Y, Shirakawa K, Yatomi T, Nakamura N, Kami
M, Saito T, Izutsu K, Asai T, Yuji K, Ogawa S, Honda H, Mitani K, Chiba
S, Yazaki Y, Hirai H. Increased soluble Fas-ligand in sera of bone marrow
transplant recipients with acute graft-versus-host disease. Bone Marrow
Transplant. 1998;22(8):751-754.
148. Kami M, Tanaka Y, Ogawa S, Kanda Y, Honda H, Chiba S, Mitani
K, Yazaki Y, Hirai H. The limitation of circulating Aspergillus antigen
detection methods for BMT recipients. Bone Marrow Transplant. 1998;22(8):832-833.
149. Kami M, Kanda Y, Sasaki M, Takeda N, Tanaka Y, Saito T,
Ogawa S, Honda H, Chiba S, Mitani K, Hirai H, Yazaki Y. Phimosis as a
manifestation of chronic graft-versus-host disease after allogeneic bone
marrow transplantation. Bone Marrow Transplant. 1998;21(7):721-723.
150. Imai Y, Kurokawa M, Tanaka K, Friedman AD, Ogawa S, Mitani
K, Yazaki Y, Hirai H. TLE, the human homolog of groucho, interacts with
AML1 and acts as a repressor of AML1-induced transactivation. Biochem
Biophys Res Commun. 1998;252(3):582-589.
151. Hosoya N, Hangaishi A, Ogawa S, Miyagawa K, Mitani K, Yazaki
Y, Hirai H. Frameshift mutations of the hMSH6 gene in human leukemia cell
lines. Jpn J Cancer Res. 1998;89(1):33-39.
152. Yamada Y, Hatta Y, Murata K, Sugawara K, Ikeda S, Mine M,
Maeda T, Hirakata Y, Kamihira S, Tsukasaki K, Ogawa S, Hirai H, Koeffler
HP, Tomonaga M. Deletions of p15 and/or p16 genes as a poor-prognosis
factor in adult T-cell leukemia. J Clin Oncol. 1997;15(5):1778-1785.
153. Tanaka T, Tanaka K, Ogawa S, Kurokawa M, Mitani K, Yazaki
Y, Shibata Y, Hirai H. An acute myeloid leukemia gene, AML1, regulates
transcriptional activation and hemopoietic myeloid cell differentiation
antagonistically by two alternative spliced forms. Leukemia. 1997;11 Suppl
3:299-302.
154. Nakamoto T, Sakai R, Honda H, Ogawa S, Ueno H, Suzuki T,
Aizawa S, Yazaki Y, Hirai H. Requirements for localization of p130cas
to focal adhesions. Mol Cell Biol. 1997;17(7):3884-3897.
155. Mitani K, Hangaishi A, Imamura N, Miyagawa K, Ogawa S, Kanda
Y, Yazaki Y, Hirai H. No concomitant occurrence of the N-ras and p53 gene
mutations in myelodysplastic syndromes. Leukemia. 1997;11(6):863-865.
156. Kanda Y, Mitani K, Tanaka T, Tanaka K, Ogawa S, Yazaki Y,
Hirai H. Subcellular localization of the MEN, MLL/MEN and truncated MLL
proteins expressed in leukemic cells carrying the t(11;19)(q23;p13.1)
translocation. Int J Hematol. 1997;66(2):189-195.
157. Hirai H, Ogawa S, Hangaishi A, Takahashi T, Kurokawa M,
Mitani K, Ueda R, Yazaki Y. Recent progress in molecular mechanisms of
leukemogenesis: the cyclin-dependent kinase 4-inhibitor gene in human
leukemias. Leukemia. 1997;11 Suppl 3:358-360.
158. Hangaishi A, Ogawa S, Mitani K, Hosoya N, Chiba S, Yazaki
Y, Hirai H. Mutations and loss of expression of a mismatch repair gene,
hMLH1, in leukemia and lymphoma cell lines. Blood. 1997;89(5):1740-1747.
159. Ogawa S, Mitani K, Kurokawa M, Matsuo Y, Minowada J, Inazawa
J, Kamada N, Tsubota T, Yazaki Y, Hirai H. Abnormal expression of Evi-1
gene in human leukemias. Hum Cell. 1996;9(4):323-332.
160. Ogawa S, Kurokawa M, Tanaka T, Tanaka K, Hangaishi A, Mitani
K, Kamada N, Yazaki Y, Hirai H. Increased Evi-1 expression is frequently
observed in blastic crisis of chronic myelocytic leukemia. Leukemia. 1996;10(5):788-794.
161. Ogawa S, Kurokawa M, Tanaka T, Mitani K, Inazawa J, Hangaishi
A, Tanaka K, Matsuo Y, Minowada J, Tsubota T, Yazaki Y, Hirai H. Structurally
altered Evi-1 protein generated in the 3q21q26 syndrome. Oncogene. 1996;13(1):183-191.
162. Ogawa S, Kurokawa M, Mitani K, Yazaki Y, Hirai H. Overexpression
of Evi-1 and dysmegakaryopoiesis in human leukemias: reply to Carapeti,
Goldman and Cross, Leukemia 1996; 10: 1561. Leukemia. 1996;10(11):1849.
163. Kurokawa M, Tanaka T, Tanaka K, Ogawa S, Mitani K, Yazaki
Y, Hirai H. Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells
leads to neoplastic transformation depending on the DNA-binding and transactivational
potencies. Oncogene. 1996;12(4):883-892.
164. Kurokawa M, Tanaka T, Tanaka K, Hirano N, Ogawa S, Mitani
K, Yazaki Y, Hirai H. A conserved cysteine residue in the runt homology
domain of AML1 is required for the DNA binding ability and the transforming
activity on fibroblasts. J Biol Chem. 1996;271(28):16870-16876.
165. Hangaishi A, Ogawa S, Imamura N, Miyawaki S, Miura Y, Uike
N, Shimazaki C, Emi N, Takeyama K, Hirosawa S, Kamada N, Kobayashi Y,
Takemoto Y, Kitani T, Toyama K, Ohtake S, Yazaki Y, Ueda R, Hirai H. Inactivation
of multiple tumor-suppressor genes involved in negative regulation of
the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes
in primary lymphoid malignancies. Blood. 1996;87(12):4949-4958.
166. Tanaka T, Tanaka K, Ogawa S, Kurokawa M, Mitani K, Nishida
J, Shibata Y, Yazaki Y, Hirai H. An acute myeloid leukemia gene, AML1,
regulates hemopoietic myeloid cell differentiation and transcriptional
activation antagonistically by two alternative spliced forms. Embo J.
1995;14(2):341-350.
167. Tanaka T, Mitani K, Kurokawa M, Ogawa S, Tanaka K, Nishida
J, Yazaki Y, Shibata Y, Hirai H. Dual functions of the AML1/Evi-1 chimeric
protein in the mechanism of leukemogenesis in t(3;21) leukemias. Mol Cell
Biol. 1995;15(5):2383-2392.
168. Tanaka K, Tanaka T, Ogawa S, Kurokawa M, Mitani K, Yazaki
Y, Hirai H. Increased expression of AML1 during retinoic-acid-induced
differentiation of U937 cells. Biochem Biophys Res Commun. 1995;211(3):1023-1030.
169. Ogawa S, Hangaishi A, Miyawaki S, Hirosawa S, Miura Y, Takeyama
K, Kamada N, Ohtake S, Uike N, Shimazaki C, et al. Loss of the cyclin-dependent
kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific
to lymphoid tumors in primary human hematopoietic malignancies. Blood.
1995;86(4):1548-1556.
170. Mitani K, Ogawa S, Tanaka T, Kurokawa M, Yazaki Y, Hirai
H. Growth inhibition of leukaemic cells carrying the t(3;21) by the AML1/EVI-1-specific
antisense oligonucleotide. Br J Haematol. 1995;90(3):711-714.
171. Mitani K, Kanda Y, Ogawa S, Tanaka T, Inazawa J, Yazaki
Y, Hirai H. Cloning of several species of MLL/MEN chimeric cDNAs in myeloid
leukemia with t(11;19)(q23;p13.1) translocation. Blood. 1995;85(8):2017-2024.
172. Kurokawa M, Ogawa S, Tanaka T, Mitani K, Yazaki Y, Witte
ON, Hirai H. The AML1/Evi-1 fusion protein in the t(3;21) translocation
exhibits transforming activity on Rat1 fibroblasts with dependence on
the Evi-1 sequence. Oncogene. 1995;11(5):833-840.
173. Gomi A, Sakai R, Ogawa S, Shinoda S, Hirai H, Masuzawa T.
Frequent loss of the cyclin-dependent kinase-4 inhibitor gene in human
gliomas. Jpn J Cancer Res. 1995;86(4):342-346.
174. Tanaka T, Nishida J, Mitani K, Ogawa S, Yazaki Y, Hirai
H. Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation
with dependence on the second zinc finger domain. J Biol Chem. 1994;269(39):24020-24026.
175. Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Nishida
J, Yazaki Y, Hirai H. Characterization, partial purification, and peptide
sequencing of p130,the main phosphoprotein associated with v-Crk oncoprotein.
J Biol Chem. 1994;269(52):32740-32746.
176. Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Mano H,
Yazaki Y, Hirai H. A novel signaling molecule, p130, forms stable complexes
in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.
Embo J. 1994;13(16):3748-3756.
177. Ogawa S, Toyoshima H, Kozutsumi H, Hagiwara K, Sakai R,
Tanaka T, Hirano N, Mano H, Yazaki Y, Hirai H. The C-terminal SH3 domain
of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation
of Crk associated p130 in rat 3Y1 cells. Oncogene. 1994;9(6):1669-1678.
178. Ogawa S, Hirano N, Sato N, Takahashi T, Hangaishi A, Tanaka
K, Kurokawa M, Tanaka T, Mitani K, Yazaki Y, et al. Homozygous loss of
the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.
Blood. 1994;84(8):2431-2435.
179. Nakamoto T, Ogawa S, Mano H, Hirai H, Yazaki Y. Hemophagocytic
syndrome associated with non-Hodgkin's lymphoma of B-cell type. Am J Hematol.
1994;47(4):335-336.
180. Mitani K, Sasaki K, Ogawa S, Hayashi Y, Mano H, Yazaki Y,
Hirai H. Molecular analysis of the t(1;19)(q23;p13) translocation observed
in adult leukemias. Int J Hematol. 1994;60(4):267-271.
181. Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano
H, Yazaki Y, Ohki M, Hirai H. Generation of the AML1-EVI-1 fusion gene
in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.
Embo J. 1994;13(3):504-510.
182. Harada H, Kondo T, Ogawa S, Tamura T, Kitagawa M, Tanaka
N, Lamphier MS, Hirai H, Taniguchi T. Accelerated exon skipping of IRF-1
mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor
inactivation. Oncogene. 1994;9(11):3313-3320.
183. Ogawa S, Mitani K, Sato Y, Sugimoto K, Toyoshima H, Mano
H, Takaku F, Yazaki Y, Hirai H. Detection of the PML/RAR alpha fusion
gene in acute promyelocytic leukemia with a complex translocation involving
chromosomes 15, 17, and 18. Cancer Genet Cytogenet. 1993;69(2):113-117.
184. Amano M, Togawa A, Tsurugano S, Soda Y, Yuo A, Takaku F,
Ogawa S, Hirai H, Yamada K. Rearrangement of retinoic acid receptor alpha
and PML in promyelocytic blast crisis of Ph1 chromosome positive chronic
myelocytic leukemia with normal copies of chromosome 15. Blood. 1993;81(9):2469-2470. Active Grants as of 2011, Nov 29.
Active grants
1. Research on Measures for Intractable Diseases, the Ministry
of Health Labour and Welfare (PI Seishi Ogawa) 2010-2012
Research on the molecular pathogenesis of myelodysplastic syndromes
to improve their outcome ¥57,413,000 2. Grant-in-Aid for Scientific Research (A), The Ministry of
Education, Culture, Sports, Science and Technology (MEXT) (PI Seishi Ogawa)
2011-2013
Research on the genetic basis of maintenance of leukemic stem
cells and recurrence and resistance of leukemia ¥36,900,000 3. Grant-in-Aid for Scientific Research on Innovative Areas,
The Ministry of Education, Culture, Sports, Science and Technology (MEXT) (PI
Seishi Ogawa) 2010-2014
Understanding of cancer heterogeneity and identification of therapeutic
targets based on SNP-array karyotyping and high-throughput sequencing
¥136,700,000 4. Project for the promotion of the next generation cancer research
strategy, The Ministry of Education, Culture, Sports, Science and Technology
(MEXT) (PI Seishi Ogawa),
Identification of epigenetic markers in myelodysplastic syndromes
and their clinical application ¥100,000,000 5. Research on Allergic disease and Immunology The Ministry
of Health Labour and Welfare (PI Yasuo Morishima) 2010-2012
Research on the histocompatibility that is related to the outcome
of hematopoietic stem cells from unrelated donors with different stem
cell sources and on the establishment of algorithm for donor selection
¥1,500,000 6. The third Term Comprehensive 10-year Strategy for Cancer
Control, The Ministry of Health Labour and Welfare (PI Toshiki Watanabe)
2009-2011 ¥7,500,000 7. Research on Measures for Intractable Diseases, The Ministry
of Health Labour and Welfare (PI Yasuhide Hayashi) 2010-2012
Research on the establishment of the classification,the guideline
for diagnosis and treatment for transient abnormal myelopoiesis in Down
syndrome ¥2,200,000 8. The third Term Comprehensive 10-year Strategy for Cancer
Control, The Ministry of Health Labour and Welfare (PI Jun Yokota) 2010-2012
Research on the molecular basis for multistep oncogenesis and
its clinical application based on comprehensive analysis of genetic abnormalities
and clinical information ¥15,100,000 9. The third Term Comprehensive 10-year Strategy for Cancer
Control, The Ministry of Health Labour and Welfare (PI Nobutaka Kiyokawa)
2010-2012
Research on molecular pathogenesis of intractable pediatric cancers ¥10,800,000 10. The project for realization of regenerative medicine, The
Ministry of Education, Culture, Sports, Science and Technology (MEXT)
(PI Hiromitsu Nakauchi) 2009-2013
Development of the next generation gene/cell therapy using human
induced pluripotent stem cells ¥70,000,000
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