Tatsuhiko Tsunoda

Professional history:

1985-1989: B.S., Department of Physics, Faculty of Science, the University of Tokyo
1989-1991: M.S., Department of Physics (Elementary Particle Physics), the University of Tokyo
1992-1995: Ph.D., Department of Engineering, the University of Tokyo
1995-1997: Assistant Professor, Department of Engineering, Kyoto University
1997-1998: Research Associate, the Human Genome Center, the Institute of Medical Science, the University of Tokyo
1998-2000: Assistant Professor, the Human Genome Center, the Institute of Medical Science, the University of Tokyo
2000-present: Laboratory Head, Laboratory for Medical Informatics, SNP Research Center (2008-present: Center for Genomic Medicine), RIKEN
2011-present: Director, Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN
2012-present: Visiting Professor, the Institute of Statistical Mathematics

Publications:

1. A.Fujimoto, Y.Totoki, T.Abe, K.A.Boroevich, F.Hosoda, H.H.Nguyen, M.Aoki, N.Hoshono, M.Kubo, F.Miya, Y.Arai, H.Takahashi, T.Shirakihara, M.Nagasaki, T.Shibuya, K.Nakano, K.Watanabe-Makino, H.Tanaka, H.Nakamura, J.Kusuda, H.Ojima, K.Shimada, T.Okusaka, M.Ueno, Y.Shigekawa, Y.Kawakami, K.Arihiro, H.Ohdan, K.Gotoh, O.Ishikawa, S.Ariizumi, M.Yamamoto, T.Yamada, K.Chayama, T.Kosuge, H.Yamaue, N.Kamatani, S.Miyano, H.Nakagama, Y.Nakamura, T.Tsunoda, T.Shibata, and H.Nakagawa. Whole Genome Sequencing of Liver Cancers Identifies Etiological Influences on Mutation Patterns and Recurrent Mutations in Chromatin Regulators. Nature Genetics, 44, 760-764 (2012).
2. T.Hirota, A.Takahashi, M.Kubo, T.Tsunoda, K.Tomita, M.Sakashita, T.Yamada, S.Fujieda, S.Tanaka, S.Doi, A.Miyatake, T.Enomoto, C.Nishiyama, N.Nakano, K.Maeda, K.Okumura, H.Ogawa, S.Ikeda, E.Noguchi, T.Sakamoto, N.Hizawa, K.Ebe, H.Saeki, T.Sasaki, T.Ebihara, M.Amagai, S.Takeuchi, M.Furue, Y.Nakamura and M.Tamari. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nature Genetics, 44, 1222-1226 (2012).
3. Y.Okada, X.Sim, M.J.Go, J-Y.Wu, D.Gu, F.Takeuchi, A.Takahashi, S.Maeda, T.Tsunoda, P.Chen, S-C.Lim, T-Y.Wong, J.Liu, T.L.Young, T.Aung, M.Seielstad, Y-Y.Teo, Y.J.Kim, J-Y.Lee, B-G.Han, D.Kang, C-H.Chen, F-J.Tsai, L-C.Chang, S-J.C.Fann, H.Mei, D.C.Rao, J.E.Hixson, S.Chen, T.Katsuya, M.Isono, T.Ogihara, J.C.Chambers, W.Zhang, J.S.Kooner, The KidneyGen Consortium, The CKDGen Consortium, E.Albrecht, The GUGC consortium, K.Yamamoto, M.Kubo, Y.Nakamura, N.Kamatani, N.Kato, J.He, Y-T.Chen, Y.S.Cho, E-S.Tai and T.Tanaka. Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations. Nature Genetics, 44, 904-909 (2012).
4. P.T.Ellinor, K.L.Lunetta, C.M.Albert, N.L.Glazer, M.D.Ritchie, A.V.Smith, D.E.Arking, M. Müller-Nurasyid, B.P.Krijthe, S.A.Lubitz, J.C.Bis, M.K.Chung, M.Dörr, K.Ozaki, J.D.Roberts, J.G.Smith, A.Pfeufer, M.F.Sinner, K.Lohman, J.Ding, N.L.Smith, J.D.Smith, M.Rienstra, K.M.Rice, D.R.Van Wagoner, J.W.Magnani, R.Wakili, S.Clauss, J.I.Rotter, G. Steinbeck, L.J.Launer, R.W.Davies, M.Borkovich, T.B.Harris, H.Lin, U.Völker, H.Völzke, D.J.Milan, A.Hofman, E.Boerwinkle, L.Y.Chen, E.Z.Soliman, B.F.Voight, G.Li, A.Chakravarti, M.Kubo, U.B.Tedrow, L.M.Rose, P.M.Ridker, D.Conen, T.Tsunoda, T.Furukawa, N.Sotoodehnia, S.Xu, N.Kamatani, D.Levy, Y.Nakamura, B.Parvez, S.Mahida, K.L.Furie, J.Rosand, R.Muhammad, B.M.Psaty, T.Meitinger, S.Perz, H-E.Wichmann, J.C.M.Witteman, W.H.L.Kao, S.Kathiresan, D.M.Roden, A.G.Uitterlinden, F.Rivadeneira, B.McKnight, M.Sjögren, A.B.Newman, Y.Liu, M.H.Gollob, O.Melander, T.Tanaka, B.H.C.Stricker, S.B.Felix, A.Alonso, D.Darbar, J.Barnard, D.I.Chasman, S.R.Heckbert, E.J.Benjamin, V.Gudnason, and S.Kääb. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics, 44, 670-5 (2012).
5. Y.Onouchi, K.Ozaki, J.C.Burns, C.Shimizu, M.Terai, H.Hamada, T.Honda, H.Suzuki, T.Suenaga, T.Takeuchi, N.Yoshikawa, Y.Suzuki, K.Yasukawa, R.Ebata, K.Higashi, T.Saji, Y.Kemmotsu, S.Takatsuki, K.Ouchi, F.Kishi, T.Yoshikawa, T.Nagai, K.Hamamoto, Y.Sato, A.Honda, H.Kobayashi, J.Sato, S.Shibuta, M.Miyawaki, K.Oishi, H.Yamaga, N.Aoyagi, S.Iwahashi, R.Miyashita, Y.Murata, K.Sasago, A.Takahashi, N.Kamatani, M.Kubo, T.Tsunoda, A.Hata, Y.Nakamura, T.Tanaka; Japan Kawasaki Disease Genome Consortium, J.Abe, T.Kobayashi, H.Arakawa, F.Ichida, Y.Nomura, M.Miura, K.Ikeda, T.Hara, R.Fukazawa, S.Ogawa, K.Hamaoka; US Kawasaki Disease Genetics Consortium, J.W.Newburger, A.L.Baker, A.H.Rowley, S.T.Shulman, M.E.Melish, W.H.Mason, M.Takahashi, and A.H.Tremoulet. A genome-wide association study identifies three new risk loci for Kawasaki disease. Nature Genetics, 44, 517 (2012).
6. Y.Okada, M.Kubo, H.Ohmiya, A.Takahashi, N.Kumasaka, N.Hosono, S.Maeda, W.Wen, R.Dorajoo, M.J.Go, W.Zheng, N.Kato, J.Y.Wu, Q.Lu, GIANT consortium, T.Tsunoda, K.Yamamoto, Y.Nakamura, N.Kamatani and T.Tanaka. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nature Genetics, 44, 302-306 (2012).
7. W.Wen, Y.S.Cho, W.Zheng, R.Dorajoo, N.Kato, L.Qi, C-H.Chen, R.J.Delahanty, Y.Okada, Y.Tabara, D.Gu, D.Zhu, C.A.Haiman, Z.Mo, Y.T.Gao, S.M.Saw, M.J.Go, F.Takeuchi, L.C.Chang, Y.Kokubo, J.Liang, M.Hao, L.L.Marchand, Y.Zhang, Y.Hu, T.Y.Wong, J.Long, B.G.Han, M.Kubo, K.Yamamoto, M.H.Su, T.Miki, B.E.Henderson, H.Song, A.Tan, J.He, D.P.Ng, Q.Cai, T.Tsunoda, F.J.Tsai, N.Iwai, G.K.Chen, J.Shi, J.Xu, X.Sim, Y.B.Xiang, S.Maeda, R.T.Ong, C.Li, Y.Nakamura, T.Aung, N.Kamatani, J.J.Liu, W.Lu, M.Yokota, M.Seielstad, C.S.Fann, The Genetic Investigation of ANthropometric Traits (GIANT) Consortium, J.Y.Wu, J.Y.Lee, F.B.Hu, T.Tanaka, E.S.Tai and X.O.Shu. Meta-analysis identifies common variants associated with body mass index in east Asians. Nature Genetics, 44, 307-311 (2012).
8. K.Myouzen, Y.Kochi, Y.Okada, C.Terao, A.Suzuki, K.Ikari, T.Tsunoda, A.Takahashi, M.Kubo, A.Taniguchi, F.Matsuda, K.Ohmura, S.Momohara, T.Mimori, H.Yamanaka, N.Kamatani, R.Yamada, Y.Nakamura, and K.Yamamoto. Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese. PLoS Genetics, 8, e1002949(2012).
9. Y.Urabe, C.Tanikawa, A.Takahashi, Y.Okada, T.Morizono, T.Tsunoda, N.Kamatani, K.Kohri, K.Chayama, M.Kubo, Y.Nakamura, and K.Matsuda. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. PLoS Genetics, 8, e1002541 (2012).
10. Y.Okada, K.Shimane, Y.Kochi, T.Tahira, A.Suzuki, K.Higasa, A.Takahashi, T.Horita, T.Atsumi, T.Ishii, A.Okamoto, K.Fujio, M.Hirakata, H.Amano, Y.Kondo, S.Ito, K.Takada, A.Mimori, K.Saito, M.Kamachi, Y.Kawaguchi, K.Ikari, O.W.Mohammed, K.Matsuda, C.Terao, K.Ohmura, K.Myouzen, N.Hosono, T.Tsunoda, N.Nishimoto, T.Mimori, F.Matsuda, Y.Tanaka, T.Sumida, H.Yamanaka, Y.Takasaki, T.Koike, T.Horiuchi, K.Hayashi, M.Kubo, N.Kamatani, R.Yamada, Y.Nakamura, and K.Yamamoto. A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese. PLoS Genetics, 8, e1002455 (2012).
11. M.Takawa, H.S.Cho, S.Hayami, G.Toyokawa, M.Kogure, Y.Yamane, Y.Iwai, K.Maejima, K.Ueda, A.Masuda, N.Dohmae, H.I.Field, T.Tsunoda, T.Kobayashi, T.Akasu, M.Sugiyama, Y.Atomi, S.I.Ohnuma, B.A.Ponder, Y.Nakamura, and R.Hamamoto. Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression. Cancer Research, 72, 3217-3227 (2012).
12. M.Imamura, S.Maeda, T.Yamauchi, K.Hara, K.Yasuda, T.Morizono, A.Takahashi, M.Horikoshi, M.Nakamura, H.Fujita, T.Tsunoda, M.Kubo, H.Watada, H.Maegawa, M.Okada-Iwabu, M.Iwabu, N.Shojima, T.Ohshige, S.Omori, M.Iwata, H.Hirose, K.Kaku, C.Ito, Y.Tanaka, K.Tobe, A.Kashiwagi, R.Kawamori, M.Kasuga, N.Kamatani; Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Y.Nakamura, and T.Kadowaki. A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Human Molecular Genetics, 21, 3042-9 (2012).
13. HH.Nguyen, R.Takata, S.Akamatsu, D.Shigemizu, T.Tsunoda, M.Furihata, A.Takahashi, M.Kubo, N.Kamatani, O.Ogawa, T.Fujioka, Y.Nakamura, and H.Nakagawa. IRX4 at 5p15 Suppresses Prostate Cancer Growth through the Interaction with Vitamin D Receptor, Conferring Prostate Cancer Susceptibility. Human Molecular Genetics, 21, 2076 (2012).
14. K.Yoshihara, T.Tsunoda, D.Shigemizu, H.Fujiwara, M.Hatae, H.Fujiwara, H.Masuzaki, H.Katabuchi, Y.Kawakami, A.Okamoto, T.Nogawa, N.Matsumura, Y.Udagawa, T.Saito, H.Itamochi, M.Takano, E.Miyagi, T.Sudo, K.Ushijima, H.Iwase, H.Seki, Y.Terao, T.Enomoto, M.Mikami, K.Akazawa, H.Tsuda, T.Moriya, A.Tajima, I.Inoue, K.Tanaka. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by down-regulation of antigen presentation pathway. Clinical Cancer Research, 18, 1374-1385 (2012).
15. H.S.Cho, G.Toyokawa, Y.Daigo, S.Hayami, K.Masuda, N.Ikawa, Y.Yamane, K.Maejima, T.Tsunoda, H.I.Field, J.D.Kelly, D.E.Neal, B.A.Ponder, Y.Maehara, Y.Nakamura, R.Hamamoto. The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G(1) /S transition in cancer cells via transcriptional regulation of the HOXA1 gene. International Journal of Cancer, 131, E179-189 (2012).
16. Y.Yamaguchi-Kabata, T.Tsunoda, N.Kumasaka, A.Takahashi, N.Hosono, M.Kubo, Y.Nakamura, and N.Kamatani. Genetic differences in the two main groups of the Japanese population based on autosomal SNPs and haplotypes. Journal of Human Genetics, 57, 326-34 (2012).
17. C.Tateno, F.Miya, K.Wake, M.Kataoka, Y.Ishida, C.Yamasaki, A.Yanagi, M.Kakuni, E.Wisse, F.Verheyen, K.Inoue, K.Sato, A.Kudo, S.Arii, T.Itamoto, T.Asahara, T.Tsunoda, and K.Yoshizato. Morphological and microarray analyses of human hepatocytes from xenogeneic host livers. Laboratory investigation, 2012 Nov 12. doi: 10.1038/labinvest.2012.158. [Epub ahead of print].
18. S.Akamatsu, A.Takahashi, R.Takata, M.Kubo, T.Inoue, T.Morizono, T.Tsunoda, N.Kamatani, C.A.Haiman, P.Wan, G.K.Chen, L.Le Marchand, L.N.Kolonel, B.E.Henderson, T.Fujioka, T.Habuchi, Y.Nakamura, O.Ogawa, H.Nakagawa. Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese. PLoS One, 7, e46454 (2012).
19. R.Nakano, T.Maekawa, H.Abe, Y.Hayashida, H.Ochi, T.Tsunoda, H.Kumada, N.Kamatani Y.Nakamura, and K.Chayama. Single nucleotide polymorphisms in GALNT8 are associated with response to interferon therapy for chronic hepatitis C. Journal of General Virology, 94, 81-89 (2013).
20. D.Kang, H.S.Cho, G.Toyokawa, M.Kogure, Y.Yamane, Y.Iwai, S.Hayami, T.Tsunoda, H.I.Field, K.Matsuda, D.E.Neal, B.A.Ponder, Y.Maehara, Y.Nakamura, and R.Hamamoto. The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis. Genes Chromosomes Cancer, 52, 126-39 (2013).
21. Y.Takahashi, I.Kou, A.Takahashi, T.A.Johnson, K.Kono, N.Kawakami, K.Uno, M.Ito, S.Minami, H.Yanagida, H.Taneichi, T.Tsuji, T.Suzuki, H.Sudo, T.Kotani, K.Watanabe, K.Chiba, N.Hosono, N.Kamatani, T.Tsunoda, Y.Toyama, M.Kubo, M.Matsumoto, and S.Ikegawa. A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. Nature Genetics, 43, 1237-1240 (2011).
22. T.Hirota, A.Takahashi, M.Kubo, T.Tsunoda, K.Tomita, S.Doi, K.Fujita, A.Miyatake, T.Enomoto, T.Miyagawa, M.Adachi, H.Tanaka, A.Niimi, H.Matsumoto, I.Ito, H.Masuko, T.Sakamoto, N.Hizawa, M.Taniguchi, J.J.Lima, C.G.Irvin, S.P.Peters, B.E.Himes, A.A.Litonjua, K.G.Tantisira, S.T.Weiss, N.Kamatani, Y.Nakamura, and M.Tamari. Genome-wide association study identifies five susceptibility loci for adult asthma in the Japanese population. Nature Genetics, 43, 893-896 (2011).
23. D.Miki, H.Ochi, C.N.Hayes, H.Abe, T.Yoshima, H.Aikata, K.Ikeda, H.Kumada, J.Toyota, T.Morizono, T.Tsunoda, M.Kubo, Y.Nakamura, N.Kamatani, and K.Chayama. Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. Nature Genetics, 43, 797-800 (2011).
24. M.A.Nalls, D.Couper, T.Tanaka, F.J.A.van Rooji, M.H.Chen, A.V.Smith, D.Toniolo, N.A.Zakai, Q.Yang, A.Greinacher, A.R.Wood, G.Melissa, P.Gasaprini, Y.Liu, T.Lumley, F.R.Aaron, A.P.Reiner, C.Geiger, V.Lagou, J.F.Felix, H.Völzke, N.A.Gouskova, A.Biffi, A.Doring, U.Völker, S.Chong, K.Wiggins, A.Rendon, A.Dehghan, M.Moore, K.Taylor, J.Wilson, G.Lettre, A.Hofman, J.C.Bis, N.Pirastu, C.S.Fox, C.Meisinger, J.Sambrook, S.Arepalli, M.Nauck, H.Prokisch, J.Stephens, N.L.Glazer, L.A.Cupples, Y.Okada, A.Takahashi, Y.Kamatani, K.Matsuda, T.Tsunoda, T.Tanaka, M.Kubo, Y.Nakamura, K.Yamamoto, N.Kamatani, M.Stumvoll, A.Tonjes, I.Prokopenko, T.Illig, K.V.Patel, S.F.Garner, B.Kuhnel, M.Mangino, B.Oostra, S.L.Thin, J.Coresh, H-E.Wichmann, S.Menzel, J.Lin, G.Pistis, A.G.Uitterlinden, T.D.Spector, A.Teumer, G.Eriksdottir, V.Gudnason, S.Bandinelli, T.Frayling, A.Chakravarti, C.M.van Duijin, D.Melzer, W.Ouwehand, D.Levy, E.Boerwinkle, A.B.Singleton, D.G.Hernandez, D.L.Longo, N.Soranzo, J.C.M.Witteman, B.M.Psaty, L.Ferrucci, T.B.Harris, C.J.O'Donnell, and S.Ganesh. Multiple loci are associated with white blood cell phenotypes. PLoS Genetics, 7, e1002113, 1-16 (2011).
25. Y.Okada, T.Hirota, Y.Kamatani, A.Takahashi, H.Ohmiya, N.Kumasaka, K.Higasa, Y.Yamaguchi-Kabata, N.Hosono, M.A.Nalls, M.H.Chen, F.J.A.van Rooij, A.V.Smith, T.Tanaka, D.J.Couper, N.A.Zakai, L.Ferrucci, D.L.Longo, D.G.Hernandez, J.C.M.Witteman, T.B.Harris, C.J.O'Donnell, S.K.Ganesh, K.Matsuda, T.Tsunoda, T.Tanaka, M.Kubo, Y.Nakamura, M.Tamari, K.Yamamoto, and N.Kamatani. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genetics, 7, e1002067, 1-10 (2011).
26. T.A.Johnson, Y.Niimura, H.Tanaka, Y.Nakamura and T.Tsunoda. hzAnalyzer: Detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets. Genome Biology, 12, R21 (2011).
27. K.Kiyotani, T.Mushiroda, T.Tsunoda, T.Morizono, N.Hosono, M.Kubo, Y.Tanigawara, CK.Imamura, DA.Flockhart, F.Aki, K.Hirata, Y.Takatsuka, M.Okazaki, S.Ohsumi, T.Yamakawa, M.Sasa, Y.Nakamura, and H.Zembutsu. A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese. Human Molecular Genetics, 21, 1665-1672 (2011).
28. H.Mbarek, H.Ochi, Y.Urabe, V.Kumar, M.Kubo, N.Hosono, A.Takahashi, Y.Kamatani, D.Miki, H.Abe, T.Tsunoda, N.Kamatani, K.Chayama, Y.Nakamura, and K.Matsuda. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Human Molecular Genetics, 20, 3884-92 (2011).
29. A.Iida, A.Takahashi, M.Kubo, S.Saito, N.Hosono, Y.Ohnishi, K.Kiyotani, T.Mushiroda, M.Nakajima, K.Ozaki, T.Tanaka, T.Tsunoda, S.Oshima, M.Sano, T.Kamei, T.Tokuda, M.Aoki, K.Hasegawa, K.Mizoguchi, M.Morita, Y.Takahashi, M.Katsuno, N.Atsuta, H.Watanabe, F.Tanaka, R.Kaji, I.Nakano, N.Kamatani, S.Tsuji, G.Sobue, Y.Nakamura, and S.Ikegawa. A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. Human Molecular Genetics, 20, 3684-3692 (2011).
30. Y.Okada, A.Takahashi, H.Ohmiya, N.Kumasaka, Y.Kamatani, N.Hosono, T.Tsunoda, K.Matsuda, T.Tanaka, M.Kubo, Y.Nakamura, K.Yamamoto, and N.Kamatani. Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Human Molecular Genetics, 20, 1224-1231 (2011).
31. M.Kato, S.Yoon, N.Hosono, A.Leotta, J.Sebat, T.Tsunoda, and M.Q.Zhang. Inferring Haplotypes of Copy Number Variations from High-Throughput Data with Uncertainty. G3: Genes, Genomes, Genetics, 1, 35-42 (2011).
32. G.Toyokawa, H.S.Cho, K.Masuda, Y.Yamane, M.Yoshimatsu, S.Hayami, M.Takawa, Y.Iwai, Y.Daigo, E.Tsuchiya, T.Tsunoda, H.I.Field, J.D.Kelly, D.E.Neal, Y.Maehara, B.A.Ponder, Y.Nakamura, R.Hamamoto. Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway. Neoplasia, 13, 887-898 (2011).
33. H.S.Cho, J.D.Kelly, S.Hayami, G.Toyokawa, M.Takawa, M.Yoshimatsu, T.Tsunoda, H.I.Field, D.E.Neal, B.A.Ponder, Y.Nakamura, and R.Hamamoto. Enhanced Expression of EHMT2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH1. Neoplasia, 13, 676-684 (2011).
34. G.Toyokawa, H.S.Cho, Y.Iwai, M.Yoshimatsu, M.Takawa, S.Hayami, K.Maejima, N.Shimizu, H.Tanaka, T.Tsunoda, H.Field, J.D.Kelly, D.E.Neal, B.A.Ponder, Y.Maehara, Y.Nakamura, and R.Hamamoto. The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prevention Research (Phila), 4, 2051-2061 (2011).
35. K.Nakabayashi, A.Tajima, K.Yamamoto, A.Takahashi, K.Hata, Y.Takashima, M.Koyanagi, H.Nakaoka, T.Akamizu, N.Ishikawa, S.Kubota, S.Maeda, T.Tsunoda, M.Kubo, N.Kamatani, Y.Nakamura, T.Sasazuki, and S.Shirasawa. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. Journal of Human Genetics, 56, 772-778 (2011).
36. M.Tsuge, Y.Fujimoto, N.Hiraga, Y.Zhang, M.Ohnishi, T.Kohno, H.Abe, D.Miki, M.Imamura, S.Takahashi, H.Ochi, C.N.Hayes, F.Miya, T.Tsunoda, and K.Chayama. Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse. PLoS One, 6, e23856 (2011).
37. V.Kumar, K.Matsuo, A.Takahashi, N.Hosono, T.Tsunoda, N.Kamatani, S.Y.Kong, H.Nakagawa, R.Cui, C.Tanikawa, M.Seto, Y.Morishima, M.Kubo, Y.Nakamura, and K.Matsuda. Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. Journal of Human Genetics, 56, 436-439 (2011).
38. Y.Hashimoto, H.Ochi, H.Abe, Y.Hayashida, M.Tsuge, F.Mitsui, N.Hiraga, M.Imamura, S.Takahashi, C.N.Hayes, W.Ohishi, M.Kubo, T.Tsunoda, N.Kamatani, Y.Nakamura, and K.Chayama. Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b. Journal of Medical Biology, 83, 981-988 (2011).
39. R.Cui, Y.Okada, S.G.Jang, J.L.Ku, J.G.Park, Y.Kamatani, N.Hosono, T.Tsunoda, V.Kumar, C.Tanikawa, N.Kamatani, R.Yamada, M.Kubo, Y.Nakamura, and K.Matsuda. Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population. Gut, 60, 799-805 (2011).
40. H.Ochi, T.Maekawa, H.Abe, Y.Hayashida, R.Nakano, M.Imamura, N.Hiraga, Y.Kawakami, S.Aimitsu, J.H.Kao, M.Kubo, T.Tsunoda, H.Kumada, Y.Nakamura, C.N.Hayes, and K.Chayama. IL-28B predicts response to chronic hepatitis C therapy - fine-mapping and replication study in Asian populations. Journal of General Virology, 92, 1071-1081 (2011).
41. M.Harada, T.Hirota, A.I.Jodo, Y.Hitomi, M.Sakashita, T.Tsunoda, T.Miyagawa, S.Doi, M.Kameda, K.Fujita, A.Miyatake, T.Enomoto, E.Noguchi, H.Masuko, T.Sakamoto, N.Hizawa, Y.Suzuki, S.Yoshihara, M.Adachi, M.Ebisawa, H.Saito, K.Matsumoto, T.Nakajima, R.A.Mathias, N.Rafaels, K.C.Barnes, B.E.Himes, Q.L.Duan, K.G.Tantisira, S.T.Weiss, Y.Nakamura, S.F.Ziegler, and M.Tamari. TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma. American Journal of Respiratory Cell and Molecular Biology, 44, 787-793 (2011).
42. C.Tateno, M.Kataoka, R.Utoh, A.Tachibana, T.Itamoto, T.Asahara, F.Miya, T.Tsunoda, and K.Yoshizato. Growth Hormone-dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-repopulated Liver. Endocrinology, 152, 1479-1491 (2011).
43. T.Kawaoka, C.N.Hayes, W.Ohishi, H.Ochi, T.Maekawa, H.Abe, M.Tsuge, F.Mitsui, N.Hiraga, M.Imamura, S.Takahashi, M.Kubo, T.Tsunoda, Y.Nakamura, H.Kumada, and K.Chayama. Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. Journal of Hepatology, 54, 408-414 (2011).
44. A.Aoki, K.Ozaki, H.Sato, A.Takahashi, M.Kubo, Y.Sakata, Y.Onouchi, T.Kawaguchi, T.H.Lin, H.Takano, M.Yasutake, P.C.Hsu, S.Ikegawa, N.Kamatani, T.Tsunoda, S.H.Juo, M.Hori, I.Komuro, K.Mizuno, Y.Nakamura, and T.Tanaka. SNPs on Chromosome 5p15.3 Associated with Myocardial Infarction in Japanese population. Journal of Human genetics, 56, 47-51 (2011).
45. Y.Kato, H.Zembutsu, R.Takata, F.Miya, T.Tsunoda, W.Obara, T.Fujioka, and Y.Nakamura. Predicting response of bladder cancers to gemcitabine and carboplatin neoadjubant chemotherapy through genome-wide gene expression profiling. Experimental and Therapeutic Medicine, 2, 47-56 (2011).
46. S.Chung, H.Nakagawa, M.Uemura, L.Piao, K.Ashikawa, N.Hosono, R.Takata, S.Akamatsu, T.Kawaguchi, T.Morizono, T.Tsunoda, Y.Daigo, K.Matsuda, N.Kamatani, Y.Nakamura, and M.Kubo. Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Science, 102, 245-252 (2011).
47. M.Yoshimatsu, G.Toyokawa, S.Hayami, M.Unoki, T.Tsunoda, H.I.Field, J.D.Kelly, D.E.Neal, Y.Maehara, B.A.Ponder, Y.Nakamura, and R.Hamamoto. Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers. International Journal of Cancer, 128, 562-573 (2011).
48. S.Hayami, J.D.Kelly, H.S.Cho, M.Yoshimatsu, M.Unoki, T.Tsunoda, H.I.Field, D.E.Neal, H.Yamaue, B.A.J.Ponder, Y.Nakamura, and R.Hamamoto. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. International Journal of Cancer, 128, 574-586 (2011).
49. A.Fujimoto, H.Nakagawa, N.Hosono, K.Nakano, T.Abe, K.A.Boroevich, M.Nagasaki, R.Yamaguchi, T.Shibuya, M.Kubo, S.Miyano, Y.Nakamura, and T.Tsunoda. Whole genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nature Genetics, 42, 931-936 (2010).
50. The International Cancer Genome Consortium. International network of cancer genome projects. Nature, 464, 993-998 (2010).
51. M.Kato, T.Kawaguchi, S.Ishikawa, T.Umeda, R.Nakamichi, M.H.Shapero, K.W.Jones, Y.Nakamura, H.Aburatani, and T.Tsunoda. Population-genetic nature of copy number variations in the human genome. Human Molecular Genetics, 19, 761-773 (2010).
52. D.Miki, M.Kubo, A.Takahashi, K.Yoon, J.Kim, G.K.Lee, J.I.Zo, J.S.Lee, N.Hosono, T.Morizono, T.Tsunoda, N.Kamatani, K.Chayama, T.Takahashi, J.Inazawa, Y.Nakamura and Y.Daigo. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nature Genetics, 42, 893-896 (2010).
53. T.Yamauchi, K.Hara, S.Maeda, K.Yasuda, A.Takahashi, M.Horikoshi, M.Nakamura, H.Fujita, N.Grarup, S.Cauchi, D.P.K.Ng, R.C.W.Ma, T.Tsunoda, M.Kubo, H.Watada, H.Maegawa, M.Okada-Iwabu, M.Iwabu, N.Shojima, H.D.Shin, G.Andersen, D.R.Witte, T.Jørgensen, T.Lauritzen, A.Sandbæk, T.Hansen, T.Ohshige, S.Omori, I.Saito, K.Kaku, H.Hirose, W.So, D.Beury, J.C.N.Chan, K.Soo.Park, E.S.Tai, C.Ito, Y.Tanaka, A.Kashiwagi, R.Kawamori, M.Kasuga, P.Froguel, O.Pedersen, N.Kamatani, Y.Nakamura, and T.Kadowaki. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics, 42, 864-868 (2010).
54. M.Nakashima, S.Chung, A.Takahashi, N.Kamatani, T.Kawaguchi, T.Tsunoda, N.Hosono, M.Kubo, Y.Nakamura, and H.Zembutsu. A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nature Genetics, 42, 768-771 (2010).
55. R.Takata, S.Akamatsu, M.Kubo, A.Takahashi, N.Hosono, T.Kawaguchi, T.Tsunoda, J.Inazawa, N.Kamatani, O.Ogawa, T.Fujioka, Y.Nakamura and H.Nakagawa. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nature Genetics, 42, 751-754 (2010).
56. Y.Kochi, Y.Okada, A.Suzuki, K.Ikari, C.Terao, A.Takahashi, K.Yamazaki, N.Hosono, K.Myouzen, T.Tsunoda, N.Kamatani, T.Furuichi, S.Ikegawa, K.Ohmura, T.Mimori, F.Matsuda, T.Iwamoto, S.Momohara, H.Yamanaka, R.Yamada, M.Kubo, Y.Nakamura and K.Yamamoto. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nature Genetics, 42, 515-519 (2010).
57. O.Mizumori, H.Zembutsu, Y.Kato, T.Tsunoda, F.Miya, T.Morizono, T.Tsukamoto, T.Fujioka, Y.Tomita, T.Kitamura, S.Ozono, T.Miki, S.Naito, H.Akaza, and Y.Nakamura. Identification of a set of genes associated with response to interleukin-2 and interferon-alpha combination therapy for renal cel carcinoma through genome-wide gene expression profiling. Experimental and Therapeutic Medicine, 1, 955-961 (2010).
58. T.Shimizu, T.Ishikawa, E.Sugihara, S.Kuninaka, T.Miyamoto, Y.Mabuchi, Y.Matsuzaki, T.Tsunoda, F.Miya, H.Morioka, R.Nakayama, E.Kobayashi, Y.Toyama, A.Kawai, H.Ichikawa, T.Hasegawa, S.Okada, T.Ito, Y.Ikeda, T.Suda, and H.Saya. c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis. Oncogene, 29, 5687-5699 (2010).
59. H.Ochi, T.Maekawa, H.Abe, Y.Hayashida, R.Nakano, M.Kubo, T.Tsunoda, C.N.Hayes, H.Kumada, Y.Nakamura, and K.Chayama. Inosine Triphosphate Pyrophosphatase Polymorphism Affects Ribavirin-induced Anemia and Outcome of Therapy - A Genome-wide Study of Japanese HCV Patients. Gastroenterology, 139, 1190-1197 (2010).
60. K.Kiyotani, T.Mushiroda, N.Hosono, T.Tsunoda, M.Kubo, F.Aki, Y.Okazaki, K.Hirata, Y.Takatsuka, M.Okazaki, S.Ohsumi, T.Yamakawa, M.Sasa, Y.Nakamura, and H.Zembutsu. Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response. Pharmacogenetics and Genomics, 20, 565-568 (2010).
61. Y.Yamaguchi-Kabata, T.Tsunoda, A.Takahashi, N.Hosono, M.Kubo, Y.Nakamura, and N.Kamatani. Making a haplotype catalog with estimated frequencies based on SNP homozygotes. Journal of Human Genetics, 55, 500-506 (2010).
62. Y.Onouchi, K.Ozaki, J.C.Buns, C.Shimizu, H.Hamada, T.Honda, M.Terai, A.Honda, T.Takeuchi, S.Shibuta, T.Suenaga, H.Suzuki, K.Higashi, K.Yasukawa, Y.Suzuki, K.Sasago, Y.Kemmotsu, S.Takatsuki, T.Saji, T.Yoshikawa, T.Nagai, K.Hamamoto, F.Kishi, K.Ouchi, Y.Sato, J.W.Newburger, A.L.Baker, S.T.Shulman, A.H.Rowley, M.Yashiro, Y.Nakamura, K.Wakui, Y.Fukushima, A.Fujino, T.Tsunoda, T.Kawasaki, A.Hata, Y.Nakamura, and T.Tanaka. Common variants in CASP3 confer susceptibility to Kawasaki disease. Human Molecular Genetics, 19, 2898-2906 (2010).
63. S.Hayami, M.Yoshimatsu, A.Veerakumarasivam, M.Unoki, Y.Iwai, T.Tsunoda, H.I.Field, J.D.Kelly, D.E.Neal, H.Yamaue, B.A.Ponder, Y.Nakamura, and R.Hamamoto. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular Cancer, 9, 59 (2010).
64. M.Nakajima, A.Takahashi, I.Kou, C.Rodriguez-Fontenla, J.J.Gomez-Reino, T.Furuichi, J.Dai, A.Sudo, A.Uchida, N.Fukui, M.Kubo, N.Kamatani, T.Tsunoda, K.N.Malizos, A.Tsezou, A.Gonzalez, Y.Nakamura, and S.Ikegawa. New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-wide Association Study. PLoS ONE, 5, e9723 (2010).
65. S.Maeda, M.A.Kobayashi, S.Araki, T.Babazono, B.I.Freedman, M.A.Bostrom, J.N.Cooke, M.Toyoda, T.Umezono, L.Tarnow, T.Hansen, P.Gaede, A.Jorsal, D.P.Ng, M.Ikeda, T.Yanagimoto, T.Tsunoda, H.Unoki, K.Kawai, M.Imanishi, D.Suzuki, H.D.Shin, K.S.Park, A.Kashiwagi, Y.Iwamoto, K.Kaku, R.Kawamori, H.H.Parving, D.W.Bowden, O.Pedersen, and Y.Nakamura. A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes. PLoS Genetics, 6, e1000842 (2010).
66. K.Kiyotani, T.Mushiroda, C.K.Imamura, N.Hosono, T.Tsunoda, M.Kubo, Y.Tanigawara, D.A.Flockhart, Z.Desta, T.C.Skaar, F.Aki, K.Hirata, Y.Takatsuka, M.Okazaki, S.Ohsumi, T.Yamakawa, M.Sasa, Y.Nakamura, and H.Zembutsu. Significant Effect of Polymorphisms in CYP2D6 and ABCC2 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Breast Cancer Patients. Journal of Clinical Oncology, 28, 1287-1293 (2010).
67. W.Satake, Y.Nakabayashi, I.Mizuta, Y.Hirota, C.Ito, M.Kubo, T.Kawaguchi, T.Tsunoda, M.Watanabe, A.Takeda, H.Tomiyama, K.Nakashima, K.Hasegawa, F.Obata, T.Yoshikawa, H.Kawakami, S.Sakoda, M.Yamamoto, N.Hattori, M.Murata, Y.Nakamura, and T.Toda. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nature Genetics, 41, 1303-1307 (2009).
68. K.Asano, T.Matsushita, J.Umeno, N.Hosono, A.Takahashi, T.Kawaguchi, T.Matsumoto, T.Matsui, Y.Kakuta, Y.Kinouchi, T.Shimosegawa, M.Hosokawa, Y.Arimura, Y.Shinomura, Y.Kiyohara, T.Tsunoda, N.Kamatani, M.Iida, Y.Nakamura and M.Kubo. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nature Genetics, 41, 1325-1329 (2009).
69. M.Sakashita, T.Hirota, M.Harada, R.Nakamichi, T.Tsunoda, Y.Osawa, A.Kojima, M.Okamoto, D.Suzuki, S.Kubo, Y.Imoto, Y.Nakamura, M.Tamari, and S.Fujieda. Prevalence of Allergic Rhinitis and Sensitization to Common Aeroallergens in a Japanese Population. International Archives of Allergy and Immunology, 151, 255-261 (2009).
70. E.Birney, T.J.Hudson, E.D.Green, C.Gunter, S.Eddy, J.Rogers, J.R.Harris, S.D.Ehrlich, R.Apweiler, C.P.Austin, L.Berglund, M.Bobrow, C.Bountra, A.J.Brookes, A.Cambon-Thomsen, N.P.Carter, R.L.Chisholm, J.L.Contreras, R.M.Cooke, W.L.Crosby, K.Dewar, R.Durbin, S.O.Dyke, J.R.Ecker, K.El Emam, L.Feuk, S.B.Gabriel, J.Gallacher, W.M.Gelbart, A.Granell, F.Guarner, T.Hubbard, S.A.Jackson, J.L.Jennings, Y.Joly, S.M.Jones, J.Kaye, K.L.Kennedy, B.M.Knoppers, N.C.Kyrpides, W.W.Lowrance, J.Luo, J.J.MacKay, L.Martín-Rivera, W.R.McCombie, J.D.McPherson, L.Miller, W.Miller, D.Moerman, V.Mooser, C.C.Morton, J.M.Ostell, B.F.Ouellette, J.Parkhill, P.S.Raina, C.Rawlings, S.E.Scherer, S.W.Scherer, P.N.Schofield, C.W.Sensen, V.C.Stodden, M.R.Sussman, T.Tanaka, J.Thornton, T.Tsunoda, D.Valle, E.I.Vuorio, N.M.Walker, S.Wallace, G.Weinstock, W.B.Whitman, K.C.Worley, C.Wu, J.Wu, and J.Yu. Prepublication data sharing. Nature, 461, 168-170 (2009).
71. R.Cui, Y.Kamatani, A.Takahashi, M.Usami, N.Hosono, T.Kawaguchi, T.Tsunoda, N.Kamatani, M.Kubo, Y.Nakamura, and K.Matsuda. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology, 137, 1768-1775 (2009).
72. A.Fujimoto, N.Nishida, R.Kimura, T.Miyagawa, R.Yuliwulandari, L.Batubara, M.S.Mustofa, U.Samakkarn, W.Settheetham-Ishida, T.Ishida, Y.Morishita, T.Tsunoda, K.Tokunaga, and J.Ohashi. FGFR2 is associated with hair thickness in Asian populations. Journal of Human Genetics, 54, 461-465 (2009).
73. J.W.Kim, M.Akiyama, J.H.Park, M.L.Lin, A.Shimo, T.Ueki, Y.Daigo, T.Tsunoda, T.Nishidate, Y.Nakamura, and T.Katagiri. Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer. Cancer Science, 100, 1468-1478 (2009).
74. N.Hosono, M.Kato, K.Kiyotani, T.Mushiroda, S.Takata, H.Sato, H.Amitani, Y.Tsuchiya, K.Yamazaki, T.Tsunoda, H.Zembutsu, Y.Nakamura, and M.Kubo. CYP2D6 genotyping for functional gene dosage analysis by allele copy number detection. Clinical Chemistry, 55, 1546-1554 (2009).
75. E.Nagata, H.Hattori, M.Kato, S.Ogasawara, S.Suzuki, M.Shibata, T.Shimizu, J.Hamada, T.Osada, R.Takaoka, M.Kuwana, T.Tsunoda, S.Aiso, S.Takizawa, N.Suzuki, and S.Takagi. Identification of biomarkers associated with migraine with aura. Neuroscience Research, 64, 104-110 (2009).
76. Y.Kamatani, S.Wattanapokayakit, H.Ochi, T.Kawaguchi, A.Takahashi, N.Hosono, M.Kubo, T.Tsunoda, N.Kamatani, H.Kumada, A.Puseenam, T.Sura, Y.Daigo, K.Chayama, W.Chantratita, Y.Nakamura, and K.Matsuda. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics, 41, 591-595 (2009).
77. K.Ozaki, H.Sato, K.Inoue, T.Tsunoda, Y.Sakata, H.Mizuno, T.Lin, Y.Miyamoto, A.Aoki, Y.Onouchi, S.Sheu, S.Ikegawa, K.Odashiro, M.Nobuyoshi, S.H.Juo, M.Hori, Y.Nakamura, and T.Tanaka. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nature Genetics, 41, 329-333 (2009).
78. H.Zembutsu, Y.Suzuki, A.Sasaki, T.Tsunoda, T.Hasegawa, K.Hirata, and Y.Nakamura. Predicting Response to Docetaxel Neoadjuvant Chemotherapy for Advanced Breast Cancers through Genome-Wide Gene Expression Profiling. International Journal of Oncology, 34, 361-370 (2009).
79. C.Fukukawa, S.Nagayama, T.Tsunoda, J.Toguchida, Y.Nakamura, and T.Katagiri. Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Oncogene, 28, 1110-1120 (2009).
80. M.Kato, Y.Nakamura, and T.Tsunoda. An Algorithm for Inferring Complex Haplotypes in a Region of Copy-Number Variation. American Journal of Human Genetics, 83, 157-169 (2008).
81. M.Kato, F.Miya, Y.Kanemura, T.Tanaka, Y.Nakamura, and T.Tsunoda. Recombination rates of genes expressed in human tissues. Human Molecular Genetics, 17, 577-586 (2008).
82. M.Kato, Y.Nakamura, and T.Tsunoda. MOCSphaser: a haplotype inference tool from a mixture of copy number variation and single nucleotide polymorphism data. Bioinformatics, 24, 1645-1646 (2008).
83. A.Suzuki, R.Yamada, Y.Kochi, T.Sawada, Y.Okada, K.Matsuda, Y.Kamatani, M.Mori, K.Shimane, Y.Hirabayashi, A.Takahashi, T.Tsunoda, A.Miyatake, M.Kubo, N.Kamatani, Y.Nakamura, and K.Yamamoto. Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nature Genetics, 40, 1224-1229 (2008).
84. H.Unoki, A.Takahashi, T.Kawaguchi, K.Hara, M.Horikoshi, G.Andersen, D.P.K.Ng, J.Holmkvist, K.Borch-Johnsen, T.Jørgensen, A.Sandbæk, T.Lauritzen, T.Hansen, S.Nurbaya, T.Tsunoda, M.Kubo, T.Babazono, H.Hirose, M.Hayashi, Y.Iwamoto, A.Kashiwagi, K.Kaku, R.Kawamori, E.S.Tai, O.Pedersen, N.Kamatani, T.Kadowaki, R.Kikkawa, Y.Nakamura, and S.Maeda. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature Genetics, 40, 1098-1102 (2008).
85. Y.Miyamoto, D.Shi, M.Nakajima, K.Ozaki, A.Sudo, A.Kotani, A.Uchida, T.Tanaka, N.Fukui, T.Tsunoda, A.Takahashi, Y.Nakamura, Q.Jiang, and S.Ikegawa. Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nature Genetics, 40, 994-998 (2008).
86. Y.Onouchi, T.Gunji, J.C. Burns, C.Shimizu, J.W. Newburger, M.Yashiro, Y.Nakamura, H.Yanagawa, K.Wakui, Y.Fukushima, F.Kishi, K.Hamamoto, M.Terai, Y.Sato, K.Ouchi, T.Saji, A.Nariai, Y.Kaburagi, T.Yoshikawa, K.Suzuki, T.Tanaka, T.Nagai, H.Cho, A.Fujino, A.Sekine, R.Nakamichi, T.Tsunoda, T.Kawasaki, Y.Nakamura, and A.Hata. A functional polymorphism in ITPKC is associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nature Genetics, 40, 35-42 (2008).
87. A.Fujimoto, J.Ohashi, N.Nishida, T.Miyagawa, Y.Morishita, T.Tsunoda, R.Kimura, and K.Tokunaga. A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia. Human Genetics, 124, 179-185 (2008).
88. I.Mizuta, T.Tsunoda, W.Satake, Y.Nakabayashi, M.Watanabe, A.Takeda, K.Hasegawa, K.Nakashima, M.Yamamoto, N.Hattori, M.Murata, and T.Toda. Calbindin1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson’s disease. Human Genetics, 124, 89-94 (2008).
89. H.Mototani, A.Iida, M.Nakajima, T.Furuichi, Y.Miyamoto, T.Tsunoda, A.Sudo, A.Kotani, A.Uchida, K.Ozaki, Y.Tanaka, Y.Nakamura, T.Tanaka, K.Notoya, and S.Ikegawa. A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Human Molecular Genetics, 17, 1790-7 (2008).
90. C.Fukukawa, H.Hanaoka, S.Nagayama, T.Tsunoda, J.Toguchida, K.Endo, Y.Nakamura, and T.Katagiri. Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. Cancer Science, 99, 432-440 (2008).
91. M.Kato and T.Tsunoda. MotifCombinator: a web-based tool to search for combinations of cis-regulatory motifs. BMC Bioinformatics, 8, 100(1-8) (2007).
92. The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature, 449, 851-862 (2007).
93. P.C.Sabeti, P.Varilly, B.Fry, J.Lohmueller, E.Hostetter, C.Cotsapas, X.Xie, E.H.Byrne, S.A.McCarroll, R.Gaudet, S.F.Schaffner, E.S.Lander, and The International HapMap Consortium. Genome-wide detection and characterization of positive selection in human populations. Nature, 449, 913-919 (2007).
94. T.Yanagiya, A.Tanabe, A.Iida, S.Saito, A.Sekine, A.Takahashi, T.Tsunoda, S.Kamohara, Y.Nakata, K.Kotani, R.Komatsu, N.Itoh, I.Mineo, J.Wada, H.Masuzaki, M.Yoneda, A.Nakajima, S.Miyazaki, K.Tokunaga, M.Kawamoto, T.Funahashi, K.Hamaguchi, K.Tanaka, K.Yamada, T.Hanafusa, S.Oikawa, H.Yoshimatsu, K.Nakao, T.Sakata, Y.Matsuzawa, N.Kamatani, Y.Nakamura, and K.Hotta. Association of single nucleotide polymorphisms in MTMR9 gene with obesity. Human Molecular Genetics, 16, 3017-3026 (2007).
95. K.Tamura, M.Furihata, T.Tsunoda, S.Ashida, R.Takata, W.Obara, H.Yoshioka, Y.Daigo, Y.Nasu, H.Kumon, H.Konaka, M.Namiki, K.Tozawa, K.Kohri, N.Tanji, M.Yokoyama, T.Shimazui, H.Akaza, Y.Mizutani, T.Miki, T.Fujioka, T.Shuin, Y.Nakamura, and H.Nakagawa. Molecular Features of Hormone-Refractory Prostate Cancer Cells by Genome-Wide Gene Expression Profiles. Cancer Research, 67, 5117-5125 (2007).
96. M.Kamiyama, M.Kobayashi, S.Araki, A.Iida, T.Tsunoda, K.Kawai, M.Imanishi, M.Nomura, T.Babazono, Y.Iwamoto, A.Kashiwagi, K.Kaku, R.Kawamori, D.Ng, T.Hansen, P.Gaede, O.Pedersen, Y.Nakamura, and S.Maeda. Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. Human Genetics, 122, 397-407 (2007).
97. A.Tanabe, T.Yanagiya, A.Iida, S.Saito, A.Sekine, A.Takahashi, T.Nakamura, T.Tsunoda, S.Kamohara, Y.Nakata, K.Kotani, R.Komatsu, N.Itoh, I.Mineo, J.Wada, T.Funahashi, S.Miyazaki, K.Tokunaga, K.Hamaguchi, T.Shimada, K.Tanaka, K.Yamada, T.Hanafusa, S.Oikawa, H.Yoshimatsu, T.Sakata, Y.Matsuzawa, N.Kamatani, Y.Nakamura, and K.Hotta. Functional SNPs in the Secretogranin III (SCG3) Gene that Forms Secretory Granules with Appetite-Related Neuropeptides are Associated with Obesity. The Journal of clinical endocrinology and metabolism, 92, 1145-1154 (2007).
98. R.Takata, T.Katagiri, M.Kanehira, T.Shuin, T.Miki, M.Namiki, K.Kohri, T.Tsunoda, T.Fujioka, and Y.Nakamura. Validation study of the prediction system for clinical responses of M-VAC neoadjuvant chemotherapy. Cancer Science, 98, 113-117 (2007).
99. M.Kato, A.Sekine, Y.Ohnishi, T.A.Johnson, T.Tanaka, Y.Nakamura, and T.Tsunoda. Linkage disequilibrium of evolutionarily conserved regions in the human genome. BMC Genomics, 7, 326(1-8) (2006).
100. T.Yokota, J.Kouno, K.Adachi, H.Takahashi, A.Teramoto, K.Matsumoto, Y.Sugisaki, M.Onda, and T.Tsunoda. Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin. Acta Neuropathologica, 111, 29-38 (2006).
101. K.Ozaki, H.Sato, A.Iida, H.Mizuno, T.Nakamura, Y.Miyamoto, A.Takahashi, T.Tsunoda, S.Ikegawa, N.Kamatani, M.Hori, Y.Nakamura, and T.Tanaka. A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. Nature Genetics, 38, 921-925 (2006).
102. Y.Onouchi, M.Tamari, A.Takahashi, T.Tsunoda, M.Yashiro, Y.Nakamura, H.Yanagawa, K.Wakui, Y.Fukushima, T.Kawasaki, Y.Nakamura, and A.Hata. A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12. Journal of Human Genetics, 52, 179-190 (2006).
103. N.Osawa, D.Koya, S.Araki, T.Uzu, T.Tsunoda, A.Kashiwagi, Y.Nakamura, and S.Maeda. Combinational effect of genes for the renin-angiotensin system in conferring susceptibility to diabetic nephropathy. Journal of Human Genetics, 52, 143-151 (2006).
104. S.Seki, Y.Kawaguchi, M.Mori, F.Mio, K.Chiba, Y.Mikami, T.Tsunoda, T.Kubo, Y.Toyama, T.Kimura, and S.Ikegawa. Association study of COL9A2 with lumber disc disease in the Japanese population. Journal of Human Genetics, 51, 1063-1067 (2006).
105. N.Jinawath, Y.Chamgramol, Y.Furukawa, K.Obama, T.Tsunoda, B.Sripa, C.Pairojkul, and Y.Nakamura. Comparison of Gene Expression Profiles Between Opisthorchis viverrini and Non-Opisthorchis viverrini Associated Human Intrahepatic Cholangiocarcinoma. Hepatology, 44, 1025-1038 (2006).
106. E.Hirota, L.Yan, T.Tsunoda, S.Ashida, M.Fujime, T.Shuin, T.Miki, Y.Nakamura, and T.Katagiri. Genome-wide gene expression profiles of clear cell renal cell carcinoma: Identification of molecular targets for treatment of renal cell carcinoma. International Journal of Oncology, 29, 799-827 (2006).
107. M.Taniwaki, Y.Daigo, N.Ishikawa, A.Takano, T.Tsunoda, W.Yasui, K.Inai, N.Kohno, and Y.Nakamura. Gene expression profiles of small-cell lung cancers: Molecular signatures of lung cancer. International Journal of Oncology, 29, 567-575 (2006).
108. T.Yamabuki, Y.Daigo, T.Kato, S.Hayama, T.Tsunoda, M.Miyamoto, T.Ito, M.Fujita, M.Hosokawa, S.Kondo, and Y.Nakamura. Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas. International Journal of Oncology, 28, 1375-1384 (2006).
109. T.Kikuchi, Y.Daigo, N.Ishikawa, T.Katagiri, T.Tsunoda, S.Yoshida, and Y.Nakamura. Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray. International Journal of Oncology, 28, 799-805 (2006).
110. The International HapMap Consortium. A haplotype map of the human genome. Nature, 437, 1299-1320 (2005).
111. S.Seki, Y.Kawaguchi, K.Chiba, Y.Mikami, H.Kizawa, T.Oya, F.Mio, M.Mori, Y.Miyamoto, I.Masuda, T.Tsunoda, M.Kamata, T.Kubo, Y.Toyama, T.Kimura, Y.Nakamura, and S.Ikegawa. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nature Genetics, 37, 607-612 (2005).
112. Y.Kochi, R.Yamada, A.Suzuki, J.B.Harley, S.Shirasawa, T.Sawada, S-C.Bae, S.Tokuhiro, X.Chang, A.Sekine, A.Takahashi, T.Tsunoda, Y.Ohnishi, K.M.Kaufman, C.P.Kang, C.Kang, S.Otsubo, W.Yumura, A.Mimori, T.Koike, Y.Nakamura, T.Sasazuki, and K.Yamamoto. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genetics, 37, 478-485 (2005).
113. K.Yamazaki, D.McGovern, J.Ragoussis, M.Paolucci, H.Butler, D.Jewwll, L.Cardon, M.Takazoe, T.Tanaka, T.Ichimori, S.Saito, A.Sekine, A.Iida, A.Takahashi, T.Tsunoda, G.M.Lathrop, and Y.Nakamura. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Human Molecular Genetics, 14, 3499-3506 (2005).
114. A.Matsuda, T.Hirota, M.Akahoshi, M.Shimizu, M.Tamari, A.Miyake, A.Takahashi, K.Nakashima, N.Takahashi, K.Obara, N.Yuyama, S.Doi, Y.Kamogawa, T.Enomoto, K.Ohshima, T.Tsunoda, S.Miyake, K.Fujita, M.Kusakabe, K.Izuhara, Y.Nakamura, J.Hopkin, and T.Shirakawa. Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma. Human Molecular Genetics, 14, 2779-2786 (2005).
115. H.Mototani, A.Mabuchi, S.Saito, M.Fujioka, A.Iida, Y.Takatori, A.Kotani, T.Kubo, K.Nakamura, A.Sekine, Y.Murakami, T.Tsunoda, K.Notoya, Y.Nakamura, and S.Ikegawa. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Human Molecular Genetics, 14, 1009-1017 (2005).
116. S.Tachiiri, T.Katagiri, T.Tsunoda, N.Oya, M.Hiraoka, and Y.Nakamura. Analysis of Gene-Expression Profiles after Gamma Irradiation of Normal Human Fibroblasts. International Journal of Radiation Oncology Biology Physics, 64, 272-279 (2005).
117. S.Maeda, S.Tsukada, A.Kanazawa, A.Sekine, T.Tsunoda, D.Koya, H.Maegawa, A.Kashiwagi, T.Babazono, M.Matsuda, Y.Tanaka, T.Fujioka, H.Hirose, T.Eguchi, Y.Ohno, C.J.Groves, A.T.Hattersley, G.A.Hitman, M.Walker, K.Kaku, Y.Iwamoto, R.Kawamori, R.Kikkawa, N.Kamatani, M.I.McCarthy, and Y.Nakamura. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. Journal of Human Genetics, 50, 283-292 (2005).
118. A.Kanazawa, Y.Kawamura, A.Sekine, A.Iida, T.Tsunoda, A.Kashiwagi, Y.Tanaka, T.Babazono, M.Matsuda, K.Kawai, T.Iizumi, T.Fujioka, M.Imanishi, K.Kaku, Y.Iwamoto, R.Kawamori, R.Kikkawa, Y.Nakamura, and S.Maeda. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. Diabetologia, 48, 1315-1322 (2005).
119. K.Obama, K.Ura, M.Li, T.Katagiri, T.Tsunoda, A.Nomura, S.Satoh, Y.Nakamura, and Y.Furukawa. Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma. Hepatology, 41, 1339-1348 (2005).
120. R.Kawaida, R.Yamada, K.Kobayashi, S.Tokuhiro, A.Suzuki, Y.Kochi, X.Chang, A.Sekine, T.Tsunoda, T.Sawada, H.Furukawa, Y.Nakamura, and K.Yamamoto. CUL1, a component of E3 ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis. Genes and Immunity, 6, 194-202 (2005).
121. R.Takata, T.Katagiri, M.Kanehira, T.Tsunoda, T.Shuin, T.Miki, M.Namiki, K.Kohri, Y.Matsushita, T.Fujioka, and Y.Nakamura. Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling. Clinical Cancer Research, 11, 2625-2636 (2005).
122. A.Shimazaki, Y.Kawamura, A.Kanazawa, A.Sekine, S.Saito, T.Tsunoda, D.Koya, T.Babazono, Y.Tanaka, M.Matsuda, K.Kawai, T.Iizumi, M.Imanishi, T.Shinosaki, T.Yanagimoto, M.Ikeda, S.Omachi, A.Kashiwagi, K.Kaku, Y.Iwamoto, R.Kawamori, R.Kikkawa, M.Nakajima, Y.Nakamura, and S.Maeda. Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Diabetes, 54, 1171-1178 (2005).
123. S.Ohtsubo, A.Iida, K.Nitta, T.Tanaka, R.Yamada, Y.Ohnishi, S.Maeda, T.Tsunoda, T.Takei, W.Obara, F.Akiyama, K.Ito, K.Honda, K.Uchida, K.Tsuchiya, W.Yumura, T.Ujiie, Y.Nagane, S.Miyano, Y.Suzuki, I.Narita, F.Gejyo, T.Fujioka, H.Nihei, and Y.Nakamura. Association of a single-nucleotide polymorphism in the immunoglobulin mu-binding protein 2 gene with immunoglobulin A nephropathy. Journal of Human Genetics, 50, 30-35 (2005).
124. T.Tsunoda, G.M.Lathrop, A.Sekine, R.Yamada, A.Takahashi, Y.Ohnishi, T.Tanaka, and Y.Nakamura. Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome. Human Molecular Genetics, 13, 1623-1632 (2004).
125. The International HapMap Consortium. Integrating ethics and science in the International HapMap Project. Nature Reviews Genetics, 5, 467-475 (2004).
126. M.Onda, M.Emi, H.Nagai, A.Yoshida, S.Miyamoto, J.Akaishi, S.Asaka, K.Mizutani, K.Shimizu, M.Nagahama, K.Ito, T.Tanaka, and T.Tsunoda. Comprehensive gene expression profiling of anaplastic thyroid cancers with cDNA microarray of 25,344 genes. Endocrine-Related Cancer, 11, 843-854 (2004).
127. T.Nagahata, M.Onda, M.Emi, H.Nagai, K.Tsumagari, T.Fujimoto, A.Hirano, T.Sato, K.Nishikawa, F.Akiyama, G.Sakamoto, F.Kasumi, Y.Miki, T.Tanaka, and T.Tsunoda. Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray. Cancer Science, 95, 218-225 (2004).
128. A.Kanazawa, S.Tsukada, A.Sekine, T.Tsunoda, A.Takahashi, A.Kashiwagi, T.Tanaka, T.Babazono, M.Matsuda, K.Kaku, Y.Iwamoto, R.Kawamori, R.Kikkawa, Y.Nakamura, and S.Maeda. Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes. American Journal of Human Genetics, 75, 832-843 (2004).
129. S.Kakiuchi, Y.Daigo, N.Ishikawa, C.Furukawa, T.Tsunoda, S.Yano, K.Nakagawa, T.Tsuruo, N.Kohno, M.Fukuoka, S.Sone, and Y.Nakamura. Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Human Molecular Genetics, 13, 3029-3043 (2004).
130. S.Ashida, H.Nakagawa, T.Katagiri, M.Fumihata, M.IIzumi, Y.Anazawa, T.Tsunoda, R.Takata, K.Kasahara, T.Miki, T.Fujioka, T.Shuin, and Y.Nakamura. Molecular Features of the Transition from Prostatic Intraepithelial Neoplasia (PIN) to Prostate Cancer: Genome-wide Gene-expression Profiles of Prostate Cancers and PINs. Cancer Research, 64, 5963-5972 (2004).
131. T.Nishidate, T.Katagiri, M.L.Lin, Y.Mano, Y.Miki, F.Kasumi, M.Yoshimoto, T.Tsunoda, K.Hirata, and Y.Nakamura. Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: Identification of genes associated with progression and metastasis. International Journal of Oncology, 25, 797-819 (2004).
132. Y.Harima, A.Togashi, K.Horikoshi, M.Imamura, M.Sougawa, S.Sawada, T.Tsunoda, Y.Nakamura, and T.Katagiri. Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. International Journal of Radiation Oncology Biology Physics, 60, 237-248 (2004).
133. N.Jinawath, Y.Furukawa, S.Hasegawa, M.Li, T.Tsunoda, S.Satoh, T.Yamaguchi, H.Imamura, M.Inoue, H.Shiozaki, and Y.Nakamura. Comparison of gene-expression profiles between diffuse- and intestinal-type gastric cancers using a genome-wide cDNA microarray. Oncogene, 23, 6830-6844 (2004).
134. M.Onda, M.Emi, H.Nagai, T.Nagahata, K.Tsumagari, T.Fujimoto, F.Akiyama, G.Sakamoto, M.Makita, F.Kasumi, Y.Miki, T.Tanaka, T.Tsunoda, and Y.Nakamura. Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers. Journal of Cancer Research and Clinical Oncology, 130, 537-545 (2004).
135. T.Nakamura, Y.Furukawa, H.Nakagawa, T.Tsunoda, H.Ohigashi, K.Murata, O.Ishikawa, K.Ohgaki, N.Kashimura, M.Miyamoto, S.Hirano, S.Kondo, H.Katoh, Y.Nakamura, and T.Katagiri. Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene, 23, 2385-2400 (2004).
136. K.Ochi, Y.Daigo, T.Katagiri, S.Nagayama, T.Tsunoda, A.Myoui, N.Naka, N.Araki, I.Kudawara, M.Ieguchi, Y.Toyama, J.Toguchida, H.Yoshikawa, and Y.Nakamura. Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles. International Journal of Oncology, 24, 647-655 (2004).
137. Y.Kochi, R.Yamada, K.Kobayashi, A.Takahashi, A.Suzuki, A.Sekine, A.Mabuchi, F.Akiyama, T.Tsunoda, Y.Nakamura, and K.Yamamoto. Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis & Rheumatism, 50, 63-71 (2004).
138. M.Li, Y-M.Lin, S.Hasegawa, T.Shimokawa, K.Murata, M.Kameyama, O.Ishikawa, T.Katagiri, T.Tsunoda, Y.Nakamura, and Y.Furukawa. Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. International Journal of Oncology, 24, 305-312 (2004).
139. The International HapMap Consortium. The International HapMap Project. Nature, 426, 789-796 (2003).
140. S.Tokuhiro, R.Yamada, X.Chang, A.Suzuki, Y.Kochi, T.Sawada, M.Suzuki, M.Nagasaki, M.Ohtsuki, M.Ono, H.Furukawa, M.Nagashima, S.Yoshino, A.Mabuchi, A.Sekine, S.Saito, A.Takahashi, T.Tsunoda, Y.Nakamura, and K.Yamamoto. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nature Genetics, 35, 341-348 (2003).
141. A.Suzuki, R.Yamada, X.Chang, S.Tokuhiro, T.Sawada, M.Suzuki, M.Nagasaki, M.Nakayama-Hamada, R.Kawaida, M.Ono, M.Ohtsuki, H.Furukawa, S.Yoshino, M.Yukioka, S.Touma, T.Matsubara, S.Wakitani, R.Teshima, A.Sekine, A.Iida, A.Takahashi, T.Tsunoda, Y.Nakamura, and K.Yamamoto. Functional haplotypes of citrullinating enzyme, peptidylarginine deiminase 4 are associated with rheumatoid arthritis. Nature Genetics, 34, 395-402 (2003).
142. N.Tanaka, T.Babazono, S.Saito, A.Sekine, T.Tsunoda, M.Haneda, Y.Tanaka, T.Fujioka, K.Kaku, R.Kawakami, R.Kikkawa, Y.Iwamoto, Y.Nakamura, and S.Maeda. Association of solute carrier family 12 (Sodium/Chloride) member 3 with diabetic nephropathy, identified by genome-wide analysis of single nucleotide polymorphisms. Diabetes, 52, 2848-2853 (2003).
143. K.Okada, T.Katagiri, T.Tsunoda, Y.Mizutani, Y.Suzuki, M.Kamada, T.Fujioka, T.Shuin, T.Miki, and Y.Nakamura. Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. International Journal of Oncology, 23, 1615-1635 (2003).
144. Y.Kaneta, Y.Kagami, T.Tsunoda, R.Ohno, Y.Nakamura, and T.Katagiri. Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray. International Journal of Oncology, 23, 681-691 (2003).
145. K.Ochi, Y.Daigo, T.Katagiri, A.Saito-Hisaminato, T.Tsunoda, Y.Toyama, H.Matsumoto, and Y.Nakamura. Expression profiles of two types of human knee-joint cartilage. Journal of Human Genetics, 48, 177-182 (2003).
146. S.Kakiuchi, Y.Daigo, T.Tsunoda, S.Yano, S.Sone, and Y.Nakamura. Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Molecular Cancer Research, 1, 485-499 (2003).
147. T.Kikuchi, Y.Daigo, T.Katagiri, T.Tsunoda, K.Okada, S.Kakiuchi, H.Zembutsu, Y.Furukawa, M.Kawamura, K.Kobayashi, K.Imai, and Y.Nakamura. Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph node metastasis and sensitivity to anti-cancer drugs. Oncogene, 22, 2192-2205 (2003).
148. W.Obara, A.Iida, Y.Suzuki, T.Tanaka, F.Akiyama, S.Maeda, Y.Ohnishi, R.Yamada, T.Tsunoda, T.Takei, K.Ito, K.Honda, K.Uchida, K.Tsuchiya, W.Yumura, T.Ujiie, Y.Nagane, K.Nitta, S.Miyano, I.Narita, F.Gejyo, H.Nihei, T.Fujioka, and Y.Nakamura. Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with Immunoglobulin A nephropathy (IgAN) in Japanese patients. Journal of Human Genetics, 48, 293-299 (2003).
149. T.Arimoto, T.Katagiri, K.Oda, T.Tsunoda, T.Yasugi, Y.Osuga, H.Yoshikawa, O.Nishii, T.Yano, Y.Taketani, and Y.Nakamura. Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. International Journal of Oncology, 22, 551-560 (2003).
150. K.Ozaki, Y.Ohnishi, A.Iida, A.Sekine, R.Yamada, T.Tsunoda, H.Sato, H.Sato, M.Hori, Y.Nakamura, and T.Tanaka. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nature Genetics, 32, 650-654 (2002).
151. S.Abe, T.Katagiri, A.Saito-Hisaminato, S.Usami, Y.Inoue, T.Tsunoda, and Y.Nakamura. Identification of CRYM as a candidate responsible for non-syndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues. American Journal of Human Genetics, 72, 73-82 (2002).
152. T.Takei, A.Iida, K.Nitta, T.Tanaka, Y.Ohnishi, R.Yamada, S.Maeda, T.Tsunoda, S.Takeoka, K.Ito, K.Honda, K.Uchida, K.Tsuchiya, Y.Suzuki, T.Fujioka, T.Ujiie, Y.Nagane, S.Miyano, I.Narita, F.Gejyo, H.Nihei, and Y.Nakamura. Association between single-nucleotide polymorphisms in selectin genes and IgA nephropathy. American Journal of Human Genetics, 70, 781-786 (2002).
153. S.Hasegawa, Y.Furukawa, M.Li, S.Satoh, T.Kato, T.Watanabe, T.Katagiri, T.Tsunoda, Y.Yamaoka, and Y.Nakamura. Genome-Wide Analysis of Gene Expression in Intestinal-Type Gastric Cancers Using a Complementary DNA Microarray Representing 23,040 Genes. Cancer Research, 62, 7012-7017 (2002).
154. S.Nagayama, T.Katagiri, T.Tsunoda, T.Hosaka, Y.Nakashima, N.Araki, K.Kusazaki, T.Nakayama, T.Tsuboyama, T.Nakamura, M.Imamura, Y.Nakamura, and J.Toguchida. Genome-wide Analysis of Gene Expression in Synovial Sarcomas Using a cDNA Microarray. Cancer Research, 62, 5859-5866 (2002).
155. S.Dan, T.Tsunoda, O.Kitahara, R.Yanagawa, H.Zembutsu, T.Katagiri, K.Yamazaki, Y.Nakamura, and T.Yamori. An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines. Cancer Research, 62, 1139-1147 (2002).
156. H.Zembutsu, Y.Ohnishi, T.Tsunoda, Y.Furukawa, T.Katagiri, Y.Ueyama, N.Tamaoki, T.Nomura, O.Kitahara, R.Yanagawa, K.Hirata, and Y.Nakamura. Genome-wide cDNA Microarray Screening to Correlate Gene Expression Profiles with Sensitivity of 85 Human Cancer Xenografts to Anticancer Drugs. Cancer Research, 62, 518-527 (2002).
157. J.Okutsu, T.Tsunoda, Y.Kaneta, T.Katagiri, O.Kitahara, H.Zembutsu, R.Yanagawa, S.Miyawaki, K.Kuriyama, N.Kubota, Y.Kimura, K.Kubo, F.Yagasaki, T.Higa, H.Taguchi, T.Tobita, H.Akiyama, A.Takeshita, Y.Wang, T.Motoji, R.Ohno, and Y.Nakamura. Prediction of Chemosensitivity for Patients with Acute Myeloid Leukemia, According to Expression Levels of 28 Genes Selected by Genome-wide Complementary DNA Microarray Analysis. Molecular Cancer Therapeutics, 1, 1035-1042 (2002).
158. F.Akiyama, T.Tanaka, R.Yamada, Y.Ohnishi, T.Tsunoda, S.Maeda, T.Takei, W.Obara, K.Ito, K.Honda, K.Uchida, K.Tsuchiya, K.Nitta, W.Yumura, H.Nihei, T.Ujiie, Y.Nagane, S.Miyano, Y.Suzuki, T.Fujioka, I.Narita, F.Gejyo, and Y.Nakamura. Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy. Journal of Human Genetics, 47, 532-538 (2002).
159. H.Ishiguro, T.Shimokawa, T.Tsunoda, T.Tanaka, Y.Fujii, Y.Nakamura, and Y.Furukawa. Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. Oncogene, 21, 6387-6394 (2002).
160. Y.Kaneta, Y.Kagami, T.Katagiri, T.Tsunoda, I.Jin-nai, H.Taguchi, H.Hirai, K.Ohnishi, T.Ueda, N.Emi, A.Tomida, T.Tsuruo, Y.Nakamura, and R.Ohno. Prediction of Sensitivity to STI571 among Chronic Myeloid Leukemia Patients by Genome-wide cDNA Microarray Analysis. Cancer Science, 93, 849-856 (2002).
161. M.Nishiu, R.Yanagawa, S.Nakatsuka, M.Yao, T.Tsunoda, Y.Nakamura, and K.Aozasa. Microarray Analysis of Gene-expression Profiles in Diffuse Large B-cell Lymphoma: Identification of Genes Related to Disease Progression. Cancer Science, 93, 894-901 (2002).
162. M.Takahashi, T.Tsunoda, M.Seiki, Y.Nakamura, and Y.Furukawa. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene, 21, 5861-5867 (2002).
163. O.Kitahara, T.Katagiri, T.Tsunoda, Y.Harima, and Y.Nakamura. Classification of Sensitivity or Resistance of Cervical Cancers to Ionizing Radiation According to Expression Profiles of 62 Genes Selected by cDNA Microarray Analysis. Neoplasia, 4, 295-303 (2002).
164. Y-M.Lin, Y.Furukawa, T.Tsunoda, C-T.Yue, K-C.Yang, and Y.Nakamura. Molecular Diagnosis of Colorectal Tumors by Expression Profiles of 50 Genes Expressed Differentially in Adenomas and Carcinomas. Oncogene, 21, 4120-4128 (2002).
165. M.Iizaka, Y.Furukawa, T.Tsunoda, H.Akashi, M.Ogawa, and Y.Nakamura. Expression Profile Analysis of Colon Cancer Cells in Response to Sulindac or Aspirin. Biochemical and Biophysical Research Communications, 292, 498-512 (2002).
166. A.Saito-Hisaminato, T.Katagiri, S.Kakiuchi, T.Nakamura, T.Tsunoda, and Y.Nakamura. Genome-Wide Profiling of Gene Expression in 29 Normal Human Tissues with a cDNA Microarray. DNA Research, 9, 35-45 (2002).
167. M.Nakamura, T.Tsunoda, and J.Obokata. Photosynthesis nuclear genes generally lack TATA-boxes: a tobacco photosystem I gene responses light through an initiator. The Plant Journal, 29, 1-10 (2002).
168. C.Kihara+, T.Tsunoda+, T.Tanaka, H.Yamana, Y.Furukawa, K.Ono, O.Kitahara, H.Zenbutsu, R.Yanagawa, K.Hirata, T.Takagi, and Y.Nakamura. Prediction of Sensitivity of Esophageal Tumors to Adjuvant Chemotherapy by cDNA Microarray Analysis of Gene-Expression Profiles. Cancer Research, 61, 6474-6479 (2001). (+ equally contributed).
169. O.Kitahara, Y.Furukawa, T.Tanaka, C.Kihara, K.Ono, R.Yanagawa, M.E.Nita, T.Takagi, Y.Nakamura, and T.Tsunoda. Alterations of Gene Expression During Colorectal Carcinogenesis Revealed by cDNA Microarrays after Laser-Capture Microdissection of Tumor Tissues and Normal Epithelia. Cancer Research, 61, 3544-3549 (2001).
170. R.Yamada, T.Tanaka, M.Unoki, T.Nagai, T.Sawada, Y.Ohnishi, T.Tsunoda, M.Yukioka, A.Maeda, K.Suzuki, H.Tateishi, T.Ochi, Y.Nakamura, and K.Yamamoto. Association between a Single-Nucleotide Polymorphism in the Promoter of the Human Interleukin-3 Gene and Rheumatoid Arthritis in Japanese Patients, and Maximum-likelihood Estimation of Combinatorial Effect That Two Genetic Loci Have on Susceptibility to the Disease. American Journal of Human Genetics, 68, 674-685 (2001).
171. M.Fujita, Y.Furukawa, T.Tsunoda, T.Tanaka, M.Ogawa, and Y.Nakamura. Up-Regulation of the Ectodermal-Neural Cortex (ENC1) Gene, a Downstream Target of the Beta-Catenin/T-Cell Factor Complex, in Colorectal Carcinomas. Cancer Research, 61, 7722-7726 (2001).
172. Y-M.Lin, K.Ono, S.Satoh, H.Ishiguro, M.Fujita, N.Miwa, T.Tanaka, T.Tsunoda, K-C.Yang, Y.Nakamura, and Y.Furukawa. Identification of AF17 as a downstream gene of the beta-catenin/Tcf pathway, and its involvement in colorecatal carcinogenesis. Cancer Research, 61, 6345-6349 (2001).
173. M.Matsushima-Nishiu, M.Unoki, K.Ono, T.Tsunoda, T.Minaguchi, H.Kuramoto, M.Nishida, T.Satoh, T.Tanaka, and Y.Nakamura. Growth and Gene-Expression Profile Analysis of Endometrial Cancer Cells Expressing Exogenous PTEN. Cancer Research, 61, 3741-3749 (2001).
174. H.Okabe, S.Satoh, T.Kato, O.Kitahara, R.Yanagawa, Y.Yamaoka, T.Tsunoda, Y.Furukawa, and Y.Nakamura. Genome-Wide Analysis of Gene Expression in Human Hepatocellular Carcinomas Using cDNA Microarray: Identification of Genes Involved in Viral Carcinogenesis and Tumor Progression. Cancer Research, 61, 2129-2137 (2001).
175. R.Yanagawa, Y.Furukawa, T.Tsunoda, O.Kitahara, K.Murata, O.Ishikawa, and Y.Nakamura. Genome-wide Screening of Genes Showing Altered Expression in Liver Metastasis of Human Colorectal Cancers by cDNA Microarray. Neoplasia, 3, 395-401 (2001).
176. H.Ishiguro, Y.Furukawa, T.Tsunoda, T.Tanaka, Y.Fujii, and Y.Nakamura. Identification of AXUD1, a novel human gene induced by AXIN1 and involved in human carcinogenesis of the lung, liver, colon, and kidney. Oncogene, 20, 5062-5066 (2001).
177. Y.Suzuki, T.Tsunoda, J.Sese, H.Taira, J. Mizushima-Sugano, H.Hata, T.Ota, T.Isogai, T.Tanaka, Y.Nakamura, A.Suyama, Y.Sakaki, S.Morishita, K.Okubo, and S.Sugano. Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes. Genome Research, 11, 677-684 (2001).
178. Y.Suzuki, H.Taira, T.Tsunoda, J. Mizushima-Sugano, J.Sese, H.Hata, T.Ota, T.Isogai, T.Tanaka, S.Morishita, K.Okubo, Y.Sakaki, Y.Nakamura, A.Suyama, and S.Sugano. Diverse Transcriptional Initiation Revealed by Fine, Large-Scale Mapping of the mRNA Start Sites. EMBO reports, 2, 388-393 (2001).
179. T.Kato, S.Satoh, H.Okabe, O.Kitahara, K.Ono, C.Kihara, T.Tanaka, T.Tsunoda, Y.Yamaoka, Y.Nakamura, and Y.Furukawa. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. Neoplasia, 3, 4-9 (2001).
180. T.Tsunoda, R.Yamada, T.Tanaka, Y.Ohnishi, and N.Kamatani. Environmental Factor Dependent Maximum Likelihood Method for Association Study Targeted to Personalized Medicine. Genome Informatics, 11, 96-105 (2000).
181. M.Kato, T.Tsunoda, and T.Takagi. Inferring Genetic Networks from DNA Microarray Data by Multiple Regression Analysis. Genome Informatics, 11, 118-128 (2000).
182. K.Ono, T.Tanaka, T.Tsunoda, O.Kitahara, C.Kihara, A.Okamoto, K.Ochiai, T.Takagi, and Y.Nakamura. Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis. Cancer Research, 60, 5007-5011 (2000).
183. Y.Ajima, K.Anraku, T.Haga, Y.Higashi, H.Honda, M.Imori, S.Inaba, N.Kimura, M.Kobayashi, Y.Makida, N.Matsui, H.Matsumoto, H.Matsunaga, M.Motoki, M.Nozaki, Y.Nishihara, J.Nishimura, S.Orito, M.Otoba, T.Saeki, T.Sanuki, M.Sasaki, K.Shimamura, J.Suzuki, K.Suzuki, N.Takimi, K.Tanaka, T.Tsunoda, I.Ueda, T.Yajima, T.Yamagami, A.Yamamoto, H.Yamaoka, T.Yoshida, and K.Yoshimura. A Superconducting Solenoidal Spectrometer for a Balloon-borne Experiment. Nuclear Instruments & Methods in Physics Research Section A – Accelerators Spectrometers Detectors and Associated Equipment, 443, 71-100 (2000).
184. T.Tsunoda, and T.Takagi. Estimating Transcription Factor Bindability on DNA. BIOINFORMATICS, 15, 622-630 (1999).
185. T.Tsunoda, M.Fukagawa, and T.Takagi. Time and Memory Efficient Algorithm for Extracting Palindromic and Repetitive Subsequences in Nucleic Acid Sequences. Pacific Symposium on Biocomputing, 202-213 (1999).
186. T.Tsunoda, and T.Takagi. Automatic Extraction of Position Specific Cooccurrence of Transcription Factor Bindings on Promoters. Pacific Symposium on Biocomputing, 252-263 (1998).
187. K.Fukuda, T.Tsunoda, A.Tamura, and T.Takagi. Toward Information Extraction: Identifying protein names from biological papers. Pacific Symposium on Biocomputing, 705-716 (1998).
188. K.Fukuda, T.Tsunoda, A.Tamura, T.Takagi. Extracting Technical Terms from Medical and Biological Articles. Transactions of Information Processing Society of Japan, 39, 2421-2430 (1998).
189. T.Tsunoda, T.Oishi, Y.Watanabe and M.Nagao. Automatic Alignment between TV News and Newspaper Articles by Maximum Length String Matching between Captions and Article Texts. Transactions of Information Processing Society of Japan, 38, 1149-1162 (1997).
190. T.Tsunoda and M.Hashiba. Disambiguation of Noun Sense by Scene Knowledge Based on Pictorial Dictionary and LDOCE Subject-Codes. Transactions of Information Processing Society of Japan, 38, 235-244 (1997).
191. M.Matsumoto, T.Tsunoda and Y.Matsumoto. A Coding Scheme which Enables Fast Direct Search in Compressed Files. The Transactions of the Institute of Electronics, Information and Communication Engineers A, J80-A, 969-976 (1997).
192. K.Araya, T.Tsunoda, T.Oishi and M.Nagao. Retrieval Method of Relevant Newspaper Articles Using Words' Cooccurrence Frequency and their Position. Transactions of Information Processing Society of Japan, 38, 855-862 (1997).
193. Y.Watanabe, Y.Okada, T.Tsunoda and M.Nagao. Aligning Articles in TV Newscasts and Newspapers. Journal of Japanese Society for Artificial Intelligence, 12, 921-927 (1997).
194. T.Tsunoda and H.Tanaka. Evaluation of Scene Information as Context for English Noun Disambiguation. Journal of Natural Language Processing, 3, 3-27 (1996).
195. T.Tsunoda, S.Nakamura, S.Orito and M.Minowa. A Search for Back-to-Back e+e- Pairs in the Spontaneous-Fission Disintegration of 252Cf. Europhys. Lett, 30, 273-276 (1995).
196. T.Tsunoda and H.Tanaka. Analysis of Scene Identification Ability of Associative Memory with Pictorial Dictionary. The 15th International Conference on Computational Linguistics (COLING 1994), 310-316 (1994).
197. K.Anraku, T.Haga, M.Imori, M.Nozaki, S.Orito, K.Shimamura, T.Tsunoda, T.Yoshida, K.Yoshimura, Y.Ajima, H.Ikeda, S.Inaba, T.Haruyama, Y.Higashi, Y.Makida, J.Suzuki, A.Yamamoto, J.Nishimura, T.Yamaguchi, R.Golden, and B.Kimbell. Search for Antiparticlees of Cosmic Origin with a Superconducting Sepectrometer. Advances in Space Research, 13, 169-172 (1993).
198. M.Imori, K.Anraku, S.Inaba, I.Ueda, T.Saeki, T.Haga, T.Tsunoda, M.Nozaki, T.Yamagami, T.Yoshida and K.Yoshimura. Real-Time Data Processes in a Balloon-borne Apparatus. IEEE Transactions on Nuclear Science, 39, 1389-1393 (1992).
199. K.Anraku, M.Imori, T.Saeki, I.Ueda, S.Inaba, K.Shimamura, M.Nozaki, T.Tsunoda and T.Yoshida. A Flash ADC System with Fast Data Compression for a Balloon-borne Experiment. IEEE Transactions on Nuclear Science, 39, 987-992 (1992).
200. T.Asanuma, M.Minowa, T.Tsukamoto, S.Orito and T.Tsunoda. A Search for Correlated e+e- Pairs in the Decay of 241Am. Physics Letters B, 237, 588-591 (1990).

Invited lectures (only international conferences are listed here):

1. T.Tsunoda. Genomic medicine’s milestones and future. Keynote lecture, International Conference on Bioinformatics 2012 (InCoB 2012), Thailand, 2012, October.
2. T.Tsunoda. Genome-wide association studies for personalized Medicine. Joint Workshop of NTU and RIKEN: From Genomics Towards Genomic Medicine. Singapore, 2007, May.
3. T.Tsunoda. Prediction of sensitivity of esophageal tumors to anti-cancer drugs by cDNA microarray analysis of gene expression profiles. Hiroshima Cancer Seminar, Hiroshima, Japan, 2000, October.
4. T.Tsunoda. Made-to-order therapy based on microarray-data and SNPs. JAACT Symposium, Fukuoka, Japan, 2000, November.

Awards:

1. The Japan Society of Human Genetics Encouraging Award in 2009.
2. The 13th Takeda Science Foundation Symposium on Bioscience on Genome Analysis and Medicine Poster Award in 2004.
3. The 48th Information Processing Society of Japan Annual Meeting Encouraging Award in 1994.
4. The International Joint Conference on Neural Networks Student Award in 1993.

Press releases:

1) A.Fujimoto, H.Nakagawa, N.Hosono, K.Nakano, T.Abe, K.A.Boroevich, M.Nagasaki, R.Yamaguchi, T.Shibuya, M.Kubo, S.Miyano, Y.Nakamura, and T.Tsunoda. Whole genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nature Genetics, 42, 931-936 (2010).
2) M.Kato, Y.Nakamura, and T.Tsunoda. An Algorithm for Inferring Complex Haplotypes in a Region of Copy-Number Variation. American Journal of Human Genetics, 83, 157-169 (2008).