Dr. Mano received his M.D. from School of Medicine, Faculty of Medicine,
University of Tokyo in 1984, and became a member of The Third Department of
Internal Medicine, Faculty of Medicine, University of Tokyo. He then received
a clinical training as a hematologist, and also started molecular biological
analyses to look for novel signaling molecules involved in the growth mechanism
of hematopoietic cells. Dr. Mano identified a novel non-receptor-type protein-tyrosine
kinase gTech, and for this discovery, Dr. Mano received his Ph.D. from The
Graduate School of Medicine, Faculty of Medicine, University of Tokyo.
Dr. Mano is currently a professor of Division of Functional Genomics at Jichi
Medical University, and focuses on the search for essential molecules in the
malignant transformation mechanism of human cancers. His group has established
to construct retroviral cDNA expression libraries from small amounts of clinical
specimens, and with such technique, they have succeeded to discover a novel
fusion-type tyrosine kinase EML4-ALK in lung cancer. Dr. Manofs group has also
developed a highly sensitive cloning method for microRNAs. Coupling such technology
with Solexa sequencer has enabled to capture thousands of microRNA candidates
in the mouse genome.
Dr. Mano has received a number of awards including the Gold Medal Award from
Tokyo Techno Forum 21 (2009), The Medical Award from The Japan Medical Association
(2008), and JCA Mauvernay Award from The Japanese Cancer Association (2008).
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