Yijun Ruan
	(Associate Director, Genomic Technologies, Genome Institute of Singapole) http://www.gis.a-star.edu.sg/internet/site/investigators.php? user_id=19&f=cv

Research Focus: My primary interest is to elucidate the structures and dynamics of all functional DNA elements in complex genomes through transcriptome characterizations and genome interrogation. To facilitate such understanding we have developed paired-end-ditag (PET) based high precision DNA sequencing and mapping methodologies. Based the PET concept, we have developed numerous DNA sequencing strategies for comprehensive characterization of transcriptomes, identification of fusion oncogenic genes, elucidation of transcription regulatory networks, mapping of genome structural variations, and de novo assembling of complex genome sequences. We are applying these sequencing-based measurements to address complex biological questions such as how cancer cells progress and how stem cells maintain their unique properties.